What's your poison? Impact of individual repair capacity on the outcomes of genotoxic therapies in cancer. Part II – information content and validity of biomarkers for individual repair capacity in the assessment of outcomes of anticancer therapy

The individual variance in the efficiency of repair of damage induced by genotoxic therapies may be an important factor in the assessment of eligibility for different anticancer treatments, the outcomes of various treatments and the therapy-associated complications, including acute and delayed toxic...

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Autores principales: Petkova, Rumena, Chelenkova, Pavlina, Georgieva, Elena, Chakarov, Stoian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Review; Medical Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433894/
https://www.ncbi.nlm.nih.gov/pubmed/26019482
http://dx.doi.org/10.1080/13102818.2014.902532
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author Petkova, Rumena
Chelenkova, Pavlina
Georgieva, Elena
Chakarov, Stoian
author_facet Petkova, Rumena
Chelenkova, Pavlina
Georgieva, Elena
Chakarov, Stoian
author_sort Petkova, Rumena
collection PubMed
description The individual variance in the efficiency of repair of damage induced by genotoxic therapies may be an important factor in the assessment of eligibility for different anticancer treatments, the outcomes of various treatments and the therapy-associated complications, including acute and delayed toxicity and acquired drug resistance. The second part of this paper analyses the currently available information about the possibilities of using experimentally obtained knowledge about individual repair capacity for the purposes of personalised medicine and healthcare.
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spelling pubmed-44338942015-05-25 What's your poison? Impact of individual repair capacity on the outcomes of genotoxic therapies in cancer. Part II – information content and validity of biomarkers for individual repair capacity in the assessment of outcomes of anticancer therapy Petkova, Rumena Chelenkova, Pavlina Georgieva, Elena Chakarov, Stoian Biotechnol Biotechnol Equip Review; Medical Biotechnology The individual variance in the efficiency of repair of damage induced by genotoxic therapies may be an important factor in the assessment of eligibility for different anticancer treatments, the outcomes of various treatments and the therapy-associated complications, including acute and delayed toxicity and acquired drug resistance. The second part of this paper analyses the currently available information about the possibilities of using experimentally obtained knowledge about individual repair capacity for the purposes of personalised medicine and healthcare. Taylor & Francis 2014-01-02 2014-05-06 /pmc/articles/PMC4433894/ /pubmed/26019482 http://dx.doi.org/10.1080/13102818.2014.902532 Text en © 2014 The Author(s). Published by Taylor & Francis. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Review; Medical Biotechnology
Petkova, Rumena
Chelenkova, Pavlina
Georgieva, Elena
Chakarov, Stoian
What's your poison? Impact of individual repair capacity on the outcomes of genotoxic therapies in cancer. Part II – information content and validity of biomarkers for individual repair capacity in the assessment of outcomes of anticancer therapy
title What's your poison? Impact of individual repair capacity on the outcomes of genotoxic therapies in cancer. Part II – information content and validity of biomarkers for individual repair capacity in the assessment of outcomes of anticancer therapy
title_full What's your poison? Impact of individual repair capacity on the outcomes of genotoxic therapies in cancer. Part II – information content and validity of biomarkers for individual repair capacity in the assessment of outcomes of anticancer therapy
title_fullStr What's your poison? Impact of individual repair capacity on the outcomes of genotoxic therapies in cancer. Part II – information content and validity of biomarkers for individual repair capacity in the assessment of outcomes of anticancer therapy
title_full_unstemmed What's your poison? Impact of individual repair capacity on the outcomes of genotoxic therapies in cancer. Part II – information content and validity of biomarkers for individual repair capacity in the assessment of outcomes of anticancer therapy
title_short What's your poison? Impact of individual repair capacity on the outcomes of genotoxic therapies in cancer. Part II – information content and validity of biomarkers for individual repair capacity in the assessment of outcomes of anticancer therapy
title_sort what's your poison? impact of individual repair capacity on the outcomes of genotoxic therapies in cancer. part ii – information content and validity of biomarkers for individual repair capacity in the assessment of outcomes of anticancer therapy
topic Review; Medical Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433894/
https://www.ncbi.nlm.nih.gov/pubmed/26019482
http://dx.doi.org/10.1080/13102818.2014.902532
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