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Relationship between vitamin D status and immunosuppressive therapy in kidney transplant recipients

There is a growing body of evidence for the protective role of vitamin D in diabetes mellitus (DM), infection, cancer, cardiovascular disease, immune disorders and kidney function. Considering the reported high prevalence of vitamin D insufficiency among kidney transplant recipients (KTRs), the aim...

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Autores principales: Filipov, Jean Jeanov, Zlatkov, Borelli Kirilov, Dimitrov, Emil Paskalev, Svinarov, Dobrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433925/
https://www.ncbi.nlm.nih.gov/pubmed/26019648
http://dx.doi.org/10.1080/13102818.2014.995415
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author Filipov, Jean Jeanov
Zlatkov, Borelli Kirilov
Dimitrov, Emil Paskalev
Svinarov, Dobrin
author_facet Filipov, Jean Jeanov
Zlatkov, Borelli Kirilov
Dimitrov, Emil Paskalev
Svinarov, Dobrin
author_sort Filipov, Jean Jeanov
collection PubMed
description There is a growing body of evidence for the protective role of vitamin D in diabetes mellitus (DM), infection, cancer, cardiovascular disease, immune disorders and kidney function. Considering the reported high prevalence of vitamin D insufficiency among kidney transplant recipients (KTRs), the aim of this study was to assess the influence of immunosuppressive therapy and other factors on vitamin D status in such patients. The study included 289 KTRs (189 males and 100 females) who consented to participate. The first test for 25-hydrohyvitamin D [25(OH)D] was performed by a validated liquid chromatography–tandem mass spectrometry method. Influence of immunosuppressive drugs and previously reported predictors on vitamin D status was assessed by descriptive statistics, univariate and multivariate regression. Our results showed that only 53 patients (18.34%) of the studied KTRs were vitamin D sufficient. In addition to a well expected positive association between serum 25(OH)D and summer blood sampling (p < 0.05) and inverse relationship between vitamin D status and DM, gender (female) and body mass index, serum 25(OH)D was found to be inversely associated with calcineurin inhibitors (CNI) (p < 0.05) and unaffected by other immunosuppressive agents. Our study demonstrated high prevalence of vitamin D insufficiency after kidney transplantation in the studied cohort of patients. Apart from female gender, winter months, DM and overweight, the use of CNI could be considered an additional significant predictor of lower 25(OH)D in Bulgarian KTRs.
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spelling pubmed-44339252015-05-25 Relationship between vitamin D status and immunosuppressive therapy in kidney transplant recipients Filipov, Jean Jeanov Zlatkov, Borelli Kirilov Dimitrov, Emil Paskalev Svinarov, Dobrin Biotechnol Biotechnol Equip Articles; Medical Biotechnology There is a growing body of evidence for the protective role of vitamin D in diabetes mellitus (DM), infection, cancer, cardiovascular disease, immune disorders and kidney function. Considering the reported high prevalence of vitamin D insufficiency among kidney transplant recipients (KTRs), the aim of this study was to assess the influence of immunosuppressive therapy and other factors on vitamin D status in such patients. The study included 289 KTRs (189 males and 100 females) who consented to participate. The first test for 25-hydrohyvitamin D [25(OH)D] was performed by a validated liquid chromatography–tandem mass spectrometry method. Influence of immunosuppressive drugs and previously reported predictors on vitamin D status was assessed by descriptive statistics, univariate and multivariate regression. Our results showed that only 53 patients (18.34%) of the studied KTRs were vitamin D sufficient. In addition to a well expected positive association between serum 25(OH)D and summer blood sampling (p < 0.05) and inverse relationship between vitamin D status and DM, gender (female) and body mass index, serum 25(OH)D was found to be inversely associated with calcineurin inhibitors (CNI) (p < 0.05) and unaffected by other immunosuppressive agents. Our study demonstrated high prevalence of vitamin D insufficiency after kidney transplantation in the studied cohort of patients. Apart from female gender, winter months, DM and overweight, the use of CNI could be considered an additional significant predictor of lower 25(OH)D in Bulgarian KTRs. Taylor & Francis 2015-03-04 2015-01-08 /pmc/articles/PMC4433925/ /pubmed/26019648 http://dx.doi.org/10.1080/13102818.2014.995415 Text en © 2015 The Author(s). Published by Taylor & Francis. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles; Medical Biotechnology
Filipov, Jean Jeanov
Zlatkov, Borelli Kirilov
Dimitrov, Emil Paskalev
Svinarov, Dobrin
Relationship between vitamin D status and immunosuppressive therapy in kidney transplant recipients
title Relationship between vitamin D status and immunosuppressive therapy in kidney transplant recipients
title_full Relationship between vitamin D status and immunosuppressive therapy in kidney transplant recipients
title_fullStr Relationship between vitamin D status and immunosuppressive therapy in kidney transplant recipients
title_full_unstemmed Relationship between vitamin D status and immunosuppressive therapy in kidney transplant recipients
title_short Relationship between vitamin D status and immunosuppressive therapy in kidney transplant recipients
title_sort relationship between vitamin d status and immunosuppressive therapy in kidney transplant recipients
topic Articles; Medical Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433925/
https://www.ncbi.nlm.nih.gov/pubmed/26019648
http://dx.doi.org/10.1080/13102818.2014.995415
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