Synthesis and in vitro activity of platinum(II) complexes of two fluorenylspirohydantoins against a human tumour cell line

This paper presents a method for synthesis and cytotoxicity of new platinum(II) complexes of (9′-fluorene)-spiro-5-hydantoin (L1) and (9′-fluorene)-spiro-5-(2-thiohydantoin) (L2). The new obtained complexes were studied by elemental analysis: ultraviolet–visible, attenuated total reflection Fourier...

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Detalles Bibliográficos
Autores principales: Marinova, Petja, Marinov, Marin, Kazakova, Maria, Feodorova, Yana, Penchev, Plamen, Sarafian, Victoria, Stoyanov, Neyko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Article; Pharmaceutical Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433959/
https://www.ncbi.nlm.nih.gov/pubmed/26019515
http://dx.doi.org/10.1080/13102818.2014.910363
Descripción
Sumario:This paper presents a method for synthesis and cytotoxicity of new platinum(II) complexes of (9′-fluorene)-spiro-5-hydantoin (L1) and (9′-fluorene)-spiro-5-(2-thiohydantoin) (L2). The new obtained complexes were studied by elemental analysis: ultraviolet–visible, attenuated total reflection Fourier transform infrared (ATR-FTIR), and (1)H- and (13)C-NMR for Pt(II) compounds and additionally Raman spectroscopy for free ligands. Based on the experimental data, the most probable structure of the complexes is suggested. In the present study, we have examined cytotoxic activity of (9′-fluorene)-spiro-5-hydantoin (L1) and (9′-fluorene)-spiro-5-(2-thiohydantoin) (L2) and their Pt(II) complexes on the retinoblastoma cell line WERI-Rb-1.

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