Synthesis and in vitro activity of platinum(II) complexes of two fluorenylspirohydantoins against a human tumour cell line

This paper presents a method for synthesis and cytotoxicity of new platinum(II) complexes of (9′-fluorene)-spiro-5-hydantoin (L1) and (9′-fluorene)-spiro-5-(2-thiohydantoin) (L2). The new obtained complexes were studied by elemental analysis: ultraviolet–visible, attenuated total reflection Fourier...

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Autores principales: Marinova, Petja, Marinov, Marin, Kazakova, Maria, Feodorova, Yana, Penchev, Plamen, Sarafian, Victoria, Stoyanov, Neyko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Article; Pharmaceutical Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433959/
https://www.ncbi.nlm.nih.gov/pubmed/26019515
http://dx.doi.org/10.1080/13102818.2014.910363
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author Marinova, Petja
Marinov, Marin
Kazakova, Maria
Feodorova, Yana
Penchev, Plamen
Sarafian, Victoria
Stoyanov, Neyko
author_facet Marinova, Petja
Marinov, Marin
Kazakova, Maria
Feodorova, Yana
Penchev, Plamen
Sarafian, Victoria
Stoyanov, Neyko
author_sort Marinova, Petja
collection PubMed
description This paper presents a method for synthesis and cytotoxicity of new platinum(II) complexes of (9′-fluorene)-spiro-5-hydantoin (L1) and (9′-fluorene)-spiro-5-(2-thiohydantoin) (L2). The new obtained complexes were studied by elemental analysis: ultraviolet–visible, attenuated total reflection Fourier transform infrared (ATR-FTIR), and (1)H- and (13)C-NMR for Pt(II) compounds and additionally Raman spectroscopy for free ligands. Based on the experimental data, the most probable structure of the complexes is suggested. In the present study, we have examined cytotoxic activity of (9′-fluorene)-spiro-5-hydantoin (L1) and (9′-fluorene)-spiro-5-(2-thiohydantoin) (L2) and their Pt(II) complexes on the retinoblastoma cell line WERI-Rb-1.
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spelling pubmed-44339592015-05-25 Synthesis and in vitro activity of platinum(II) complexes of two fluorenylspirohydantoins against a human tumour cell line Marinova, Petja Marinov, Marin Kazakova, Maria Feodorova, Yana Penchev, Plamen Sarafian, Victoria Stoyanov, Neyko Biotechnol Biotechnol Equip Article; Pharmaceutical Biotechnology This paper presents a method for synthesis and cytotoxicity of new platinum(II) complexes of (9′-fluorene)-spiro-5-hydantoin (L1) and (9′-fluorene)-spiro-5-(2-thiohydantoin) (L2). The new obtained complexes were studied by elemental analysis: ultraviolet–visible, attenuated total reflection Fourier transform infrared (ATR-FTIR), and (1)H- and (13)C-NMR for Pt(II) compounds and additionally Raman spectroscopy for free ligands. Based on the experimental data, the most probable structure of the complexes is suggested. In the present study, we have examined cytotoxic activity of (9′-fluorene)-spiro-5-hydantoin (L1) and (9′-fluorene)-spiro-5-(2-thiohydantoin) (L2) and their Pt(II) complexes on the retinoblastoma cell line WERI-Rb-1. Taylor & Francis 2014-03-04 2014-07-10 /pmc/articles/PMC4433959/ /pubmed/26019515 http://dx.doi.org/10.1080/13102818.2014.910363 Text en © 2014 The Author(s). Published by Taylor & Francis. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Article; Pharmaceutical Biotechnology
Marinova, Petja
Marinov, Marin
Kazakova, Maria
Feodorova, Yana
Penchev, Plamen
Sarafian, Victoria
Stoyanov, Neyko
Synthesis and in vitro activity of platinum(II) complexes of two fluorenylspirohydantoins against a human tumour cell line
title Synthesis and in vitro activity of platinum(II) complexes of two fluorenylspirohydantoins against a human tumour cell line
title_full Synthesis and in vitro activity of platinum(II) complexes of two fluorenylspirohydantoins against a human tumour cell line
title_fullStr Synthesis and in vitro activity of platinum(II) complexes of two fluorenylspirohydantoins against a human tumour cell line
title_full_unstemmed Synthesis and in vitro activity of platinum(II) complexes of two fluorenylspirohydantoins against a human tumour cell line
title_short Synthesis and in vitro activity of platinum(II) complexes of two fluorenylspirohydantoins against a human tumour cell line
title_sort synthesis and in vitro activity of platinum(ii) complexes of two fluorenylspirohydantoins against a human tumour cell line
topic Article; Pharmaceutical Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433959/
https://www.ncbi.nlm.nih.gov/pubmed/26019515
http://dx.doi.org/10.1080/13102818.2014.910363
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