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High mortality due to accidental salinomycin intoxication in sheep
In February 2012, 100% mortality was reported in a herd with 79 local sheep that were kept around of Abhar, Northwest of Iran. The ration for adult sheep was daily mixed (40 kg straw, 25 kg wheat and 2 kg Vit-C premix) and accidentally 1 500 g of salinomycin (Salinomycin 12% Premix; Aras Bazar Labor...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Slovak Toxicology Society SETOX
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434112/ https://www.ncbi.nlm.nih.gov/pubmed/26109896 http://dx.doi.org/10.2478/intox-2014-0024 |
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author | Ashrafihelan, Javad Eisapour, Hamed Erfani, Amir Mehdi Kalantary, Amir Ali Amoli, Jamileh Salar Mozafari, Morteza |
author_facet | Ashrafihelan, Javad Eisapour, Hamed Erfani, Amir Mehdi Kalantary, Amir Ali Amoli, Jamileh Salar Mozafari, Morteza |
author_sort | Ashrafihelan, Javad |
collection | PubMed |
description | In February 2012, 100% mortality was reported in a herd with 79 local sheep that were kept around of Abhar, Northwest of Iran. The ration for adult sheep was daily mixed (40 kg straw, 25 kg wheat and 2 kg Vit-C premix) and accidentally 1 500 g of salinomycin (Salinomycin 12% Premix; Aras Bazar Laboratories, Iran) had been added to the ration (22388 mg/kg = 22388 ppm) and overnight was fed to herd. At the morning, 78 sheep were founded dead and one of them showed convulsive seizures. Postmortem examination revealed pulmonary congestion and edema, hemorrhages in abomasum, large pale kidney and white streak lines in myocardium. Main histopathologic lesions were extensive subepicardial and intercardiomyofibers hemorrhages, extensive cardiomyolysis and myocarditis in heart, severe hyperemia and extensive acute tubular necrosis (ATN) in kidneys and focal necrosis and retention of bile cholangitis in the liver. In this study, on the basis of the history, observation of the ionophore remnant in the ration, clinical signs, gross and histopathological findings, acute salinomycin intoxication is definitely diagnosed. |
format | Online Article Text |
id | pubmed-4434112 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Slovak Toxicology Society SETOX |
record_format | MEDLINE/PubMed |
spelling | pubmed-44341122015-06-24 High mortality due to accidental salinomycin intoxication in sheep Ashrafihelan, Javad Eisapour, Hamed Erfani, Amir Mehdi Kalantary, Amir Ali Amoli, Jamileh Salar Mozafari, Morteza Interdiscip Toxicol Case Report In February 2012, 100% mortality was reported in a herd with 79 local sheep that were kept around of Abhar, Northwest of Iran. The ration for adult sheep was daily mixed (40 kg straw, 25 kg wheat and 2 kg Vit-C premix) and accidentally 1 500 g of salinomycin (Salinomycin 12% Premix; Aras Bazar Laboratories, Iran) had been added to the ration (22388 mg/kg = 22388 ppm) and overnight was fed to herd. At the morning, 78 sheep were founded dead and one of them showed convulsive seizures. Postmortem examination revealed pulmonary congestion and edema, hemorrhages in abomasum, large pale kidney and white streak lines in myocardium. Main histopathologic lesions were extensive subepicardial and intercardiomyofibers hemorrhages, extensive cardiomyolysis and myocarditis in heart, severe hyperemia and extensive acute tubular necrosis (ATN) in kidneys and focal necrosis and retention of bile cholangitis in the liver. In this study, on the basis of the history, observation of the ionophore remnant in the ration, clinical signs, gross and histopathological findings, acute salinomycin intoxication is definitely diagnosed. Slovak Toxicology Society SETOX 2014-09 2014-12-30 /pmc/articles/PMC4434112/ /pubmed/26109896 http://dx.doi.org/10.2478/intox-2014-0024 Text en Copyright © 2014 SETOX & Institute of Experimental Pharmacology and Toxicology, SASc. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Ashrafihelan, Javad Eisapour, Hamed Erfani, Amir Mehdi Kalantary, Amir Ali Amoli, Jamileh Salar Mozafari, Morteza High mortality due to accidental salinomycin intoxication in sheep |
title | High mortality due to accidental salinomycin intoxication in sheep |
title_full | High mortality due to accidental salinomycin intoxication in sheep |
title_fullStr | High mortality due to accidental salinomycin intoxication in sheep |
title_full_unstemmed | High mortality due to accidental salinomycin intoxication in sheep |
title_short | High mortality due to accidental salinomycin intoxication in sheep |
title_sort | high mortality due to accidental salinomycin intoxication in sheep |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434112/ https://www.ncbi.nlm.nih.gov/pubmed/26109896 http://dx.doi.org/10.2478/intox-2014-0024 |
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