Strong Ligand-Protein Interactions Derived from Diffuse Ligand Interactions with Loose Binding Sites

Many systems in biology rely on binding of ligands to target proteins in a single high-affinity conformation with a favorable ΔG. Alternatively, interactions of ligands with protein regions that allow diffuse binding, distributed over multiple sites and conformations, can exhibit favorable ΔG becaus...

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Detalles Bibliográficos
Autor principal: Marsh, Lorraine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434174/
https://www.ncbi.nlm.nih.gov/pubmed/26064949
http://dx.doi.org/10.1155/2015/746980

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434174/
https://www.ncbi.nlm.nih.gov/pubmed/26064949
http://dx.doi.org/10.1155/2015/746980

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