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Strong Ligand-Protein Interactions Derived from Diffuse Ligand Interactions with Loose Binding Sites
Many systems in biology rely on binding of ligands to target proteins in a single high-affinity conformation with a favorable ΔG. Alternatively, interactions of ligands with protein regions that allow diffuse binding, distributed over multiple sites and conformations, can exhibit favorable ΔG becaus...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Hindawi Publishing Corporation
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434174/ https://www.ncbi.nlm.nih.gov/pubmed/26064949 http://dx.doi.org/10.1155/2015/746980 |