The In Vivo Granulopoietic Response to Dexamethasone Injection Is Abolished in Perforin-Deficient Mutant Mice and Corrected by Lymphocyte Transfer from Nonsensitized Wild-Type Donors

Exogenously administered glucocorticoids enhance eosinophil and neutrophil granulocyte production from murine bone-marrow. A hematological response dependent on endogenous glucocorticoids underlies bone-marrow eosinophilia induced by trauma or allergic sensitization/challenge. We detected a defect i...

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Detalles Bibliográficos
Autores principales: Xavier-Elsas, Pedro, da Silva, Cássio Luiz Coutinho Almeida, Vieira, Bruno Marques, Masid-de-Brito, Daniela, Queto, Túlio, de Luca, Bianca, Vieira, Thiago Soares de Souza, Gaspar-Elsas, Maria Ignez C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434200/
https://www.ncbi.nlm.nih.gov/pubmed/26063973
http://dx.doi.org/10.1155/2015/495430

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