Cargando…

Oxygenator Is the Main Responsible for Leukocyte Activation in Experimental Model of Extracorporeal Circulation: A Cautionary Tale

In order to assess mechanisms underlying inflammatory activation during extracorporeal circulation (ECC), several small animal models of ECC have been proposed recently. The majority of them are based on home-made, nonstandardized, and hardly reproducible oxygenators. The present study has generated...

Descripción completa

Detalles Bibliográficos
Autores principales: Rungatscher, Alessio, Tessari, Maddalena, Stranieri, Chiara, Solani, Erika, Linardi, Daniele, Milani, Elisabetta, Montresor, Alessio, Merigo, Flavia, Salvetti, Beatrice, Menon, Tiziano, Faggian, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434202/
https://www.ncbi.nlm.nih.gov/pubmed/26063972
http://dx.doi.org/10.1155/2015/484979
Descripción
Sumario:In order to assess mechanisms underlying inflammatory activation during extracorporeal circulation (ECC), several small animal models of ECC have been proposed recently. The majority of them are based on home-made, nonstandardized, and hardly reproducible oxygenators. The present study has generated fundamental information on the role of oxygenator of ECC in activating inflammatory signaling pathways on leukocytes, leading to systemic inflammatory response, and organ dysfunction. The present results suggest that experimental animal models of ECC used in translational research on inflammatory response should be based on standardized, reproducible oxygenators with clinical characteristics.