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Oxygenator Is the Main Responsible for Leukocyte Activation in Experimental Model of Extracorporeal Circulation: A Cautionary Tale

In order to assess mechanisms underlying inflammatory activation during extracorporeal circulation (ECC), several small animal models of ECC have been proposed recently. The majority of them are based on home-made, nonstandardized, and hardly reproducible oxygenators. The present study has generated...

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Autores principales: Rungatscher, Alessio, Tessari, Maddalena, Stranieri, Chiara, Solani, Erika, Linardi, Daniele, Milani, Elisabetta, Montresor, Alessio, Merigo, Flavia, Salvetti, Beatrice, Menon, Tiziano, Faggian, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434202/
https://www.ncbi.nlm.nih.gov/pubmed/26063972
http://dx.doi.org/10.1155/2015/484979
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author Rungatscher, Alessio
Tessari, Maddalena
Stranieri, Chiara
Solani, Erika
Linardi, Daniele
Milani, Elisabetta
Montresor, Alessio
Merigo, Flavia
Salvetti, Beatrice
Menon, Tiziano
Faggian, Giuseppe
author_facet Rungatscher, Alessio
Tessari, Maddalena
Stranieri, Chiara
Solani, Erika
Linardi, Daniele
Milani, Elisabetta
Montresor, Alessio
Merigo, Flavia
Salvetti, Beatrice
Menon, Tiziano
Faggian, Giuseppe
author_sort Rungatscher, Alessio
collection PubMed
description In order to assess mechanisms underlying inflammatory activation during extracorporeal circulation (ECC), several small animal models of ECC have been proposed recently. The majority of them are based on home-made, nonstandardized, and hardly reproducible oxygenators. The present study has generated fundamental information on the role of oxygenator of ECC in activating inflammatory signaling pathways on leukocytes, leading to systemic inflammatory response, and organ dysfunction. The present results suggest that experimental animal models of ECC used in translational research on inflammatory response should be based on standardized, reproducible oxygenators with clinical characteristics.
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spelling pubmed-44342022015-06-10 Oxygenator Is the Main Responsible for Leukocyte Activation in Experimental Model of Extracorporeal Circulation: A Cautionary Tale Rungatscher, Alessio Tessari, Maddalena Stranieri, Chiara Solani, Erika Linardi, Daniele Milani, Elisabetta Montresor, Alessio Merigo, Flavia Salvetti, Beatrice Menon, Tiziano Faggian, Giuseppe Mediators Inflamm Research Article In order to assess mechanisms underlying inflammatory activation during extracorporeal circulation (ECC), several small animal models of ECC have been proposed recently. The majority of them are based on home-made, nonstandardized, and hardly reproducible oxygenators. The present study has generated fundamental information on the role of oxygenator of ECC in activating inflammatory signaling pathways on leukocytes, leading to systemic inflammatory response, and organ dysfunction. The present results suggest that experimental animal models of ECC used in translational research on inflammatory response should be based on standardized, reproducible oxygenators with clinical characteristics. Hindawi Publishing Corporation 2015 2015-05-04 /pmc/articles/PMC4434202/ /pubmed/26063972 http://dx.doi.org/10.1155/2015/484979 Text en Copyright © 2015 Alessio Rungatscher et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Rungatscher, Alessio
Tessari, Maddalena
Stranieri, Chiara
Solani, Erika
Linardi, Daniele
Milani, Elisabetta
Montresor, Alessio
Merigo, Flavia
Salvetti, Beatrice
Menon, Tiziano
Faggian, Giuseppe
Oxygenator Is the Main Responsible for Leukocyte Activation in Experimental Model of Extracorporeal Circulation: A Cautionary Tale
title Oxygenator Is the Main Responsible for Leukocyte Activation in Experimental Model of Extracorporeal Circulation: A Cautionary Tale
title_full Oxygenator Is the Main Responsible for Leukocyte Activation in Experimental Model of Extracorporeal Circulation: A Cautionary Tale
title_fullStr Oxygenator Is the Main Responsible for Leukocyte Activation in Experimental Model of Extracorporeal Circulation: A Cautionary Tale
title_full_unstemmed Oxygenator Is the Main Responsible for Leukocyte Activation in Experimental Model of Extracorporeal Circulation: A Cautionary Tale
title_short Oxygenator Is the Main Responsible for Leukocyte Activation in Experimental Model of Extracorporeal Circulation: A Cautionary Tale
title_sort oxygenator is the main responsible for leukocyte activation in experimental model of extracorporeal circulation: a cautionary tale
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434202/
https://www.ncbi.nlm.nih.gov/pubmed/26063972
http://dx.doi.org/10.1155/2015/484979
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