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Bone Loss Triggered by the Cytokine Network in Inflammatory Autoimmune Diseases

Bone remodeling is a lifelong process in vertebrates that relies on the correct balance between bone resorption by osteoclasts and bone formation by osteoblasts. Bone loss and fracture risk are implicated in inflammatory autoimmune diseases such as rheumatoid arthritis, ankylosing spondylitis, infla...

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Detalles Bibliográficos
Autores principales: Amarasekara, Dulshara Sachini, Yu, Jiyeon, Rho, Jaerang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434203/
https://www.ncbi.nlm.nih.gov/pubmed/26065006
http://dx.doi.org/10.1155/2015/832127
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author Amarasekara, Dulshara Sachini
Yu, Jiyeon
Rho, Jaerang
author_facet Amarasekara, Dulshara Sachini
Yu, Jiyeon
Rho, Jaerang
author_sort Amarasekara, Dulshara Sachini
collection PubMed
description Bone remodeling is a lifelong process in vertebrates that relies on the correct balance between bone resorption by osteoclasts and bone formation by osteoblasts. Bone loss and fracture risk are implicated in inflammatory autoimmune diseases such as rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease, and systemic lupus erythematosus. The network of inflammatory cytokines produced during chronic inflammation induces an uncoupling of bone formation and resorption, resulting in significant bone loss in patients with inflammatory autoimmune diseases. Here, we review and discuss the involvement of the inflammatory cytokine network in the pathophysiological aspects and the therapeutic advances in inflammatory autoimmune diseases.
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spelling pubmed-44342032015-06-10 Bone Loss Triggered by the Cytokine Network in Inflammatory Autoimmune Diseases Amarasekara, Dulshara Sachini Yu, Jiyeon Rho, Jaerang J Immunol Res Review Article Bone remodeling is a lifelong process in vertebrates that relies on the correct balance between bone resorption by osteoclasts and bone formation by osteoblasts. Bone loss and fracture risk are implicated in inflammatory autoimmune diseases such as rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease, and systemic lupus erythematosus. The network of inflammatory cytokines produced during chronic inflammation induces an uncoupling of bone formation and resorption, resulting in significant bone loss in patients with inflammatory autoimmune diseases. Here, we review and discuss the involvement of the inflammatory cytokine network in the pathophysiological aspects and the therapeutic advances in inflammatory autoimmune diseases. Hindawi Publishing Corporation 2015 2015-05-04 /pmc/articles/PMC4434203/ /pubmed/26065006 http://dx.doi.org/10.1155/2015/832127 Text en Copyright © 2015 Dulshara Sachini Amarasekara et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Amarasekara, Dulshara Sachini
Yu, Jiyeon
Rho, Jaerang
Bone Loss Triggered by the Cytokine Network in Inflammatory Autoimmune Diseases
title Bone Loss Triggered by the Cytokine Network in Inflammatory Autoimmune Diseases
title_full Bone Loss Triggered by the Cytokine Network in Inflammatory Autoimmune Diseases
title_fullStr Bone Loss Triggered by the Cytokine Network in Inflammatory Autoimmune Diseases
title_full_unstemmed Bone Loss Triggered by the Cytokine Network in Inflammatory Autoimmune Diseases
title_short Bone Loss Triggered by the Cytokine Network in Inflammatory Autoimmune Diseases
title_sort bone loss triggered by the cytokine network in inflammatory autoimmune diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434203/
https://www.ncbi.nlm.nih.gov/pubmed/26065006
http://dx.doi.org/10.1155/2015/832127
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