Generation and Characterization of a Transgenic Mouse Carrying a Functional Human β-Globin Gene with the IVSI-6 Thalassemia Mutation

Mouse models that carry mutations causing thalassemia represent a suitable tool to test in vivo new mutation-specific therapeutic approaches. Transgenic mice carrying the β-globin IVSI-6 mutation (the most frequent in Middle-Eastern regions and recurrent in Italy and Greece) are, at present, not ava...

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Detalles Bibliográficos
Autores principales: Breveglieri, Giulia, Mancini, Irene, Bianchi, Nicoletta, Lampronti, Ilaria, Salvatori, Francesca, Fabbri, Enrica, Zuccato, Cristina, Cosenza, Lucia C., Montagner, Giulia, Borgatti, Monica, Altruda, Fiorella, Fagoonee, Sharmila, Carandina, Gianni, Rubini, Michele, Aiello, Vincenzo, Breda, Laura, Rivella, Stefano, Gambari, Roberto, Finotti, Alessia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434229/
https://www.ncbi.nlm.nih.gov/pubmed/26097845
http://dx.doi.org/10.1155/2015/687635

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