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Genome-wide co-occupancy of AML1-ETO and N-CoR defines the t(8;21) AML signature in leukemic cells

BACKGROUND: Many leukemias result from chromosomal rearrangements. The t(8;21) chromosomal translocation produces AML1-ETO, an oncogenic fusion protein that compromises the function of AML1, a transcription factor critical for myeloid cell differentiation. Because of the pressing need for new therap...

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Detalles Bibliográficos
Autores principales:	Trombly, Daniel J, Whitfield, Troy W, Padmanabhan, Srivatsan, Gordon, Jonathan AR, Lian, Jane B, van Wijnen, Andre J, Zaidi, Sayyed K, Stein, Janet L, Stein, Gary S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434520/ https://www.ncbi.nlm.nih.gov/pubmed/25928846 http://dx.doi.org/10.1186/s12864-015-1445-0

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