Cargando…

Microalbuminuria and left ventricular hypertrophy among newly diagnosed black African hypertensive patients: a cross sectional study from a tertiary hospital in Uganda

BACKGROUND: Microalbuminuria is an early manifestation of kidney damage and independently predicts cardiovascular disease (CVD). Left ventricular hypertrophy (LVH) is also an early marker of cardiac manifestation of target organ damage among hypertensive patients. The prognostic significance of micr...

Descripción completa

Detalles Bibliográficos
Autores principales: Nabbaale, Juliet, Kibirige, Davis, Ssekasanvu, Emmanuel, Sebatta, Elias S, Kayima, James, Lwabi, Peter, Kalyesubula, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434545/
https://www.ncbi.nlm.nih.gov/pubmed/25971452
http://dx.doi.org/10.1186/s13104-015-1156-2
_version_ 1782371784065024000
author Nabbaale, Juliet
Kibirige, Davis
Ssekasanvu, Emmanuel
Sebatta, Elias S
Kayima, James
Lwabi, Peter
Kalyesubula, Robert
author_facet Nabbaale, Juliet
Kibirige, Davis
Ssekasanvu, Emmanuel
Sebatta, Elias S
Kayima, James
Lwabi, Peter
Kalyesubula, Robert
author_sort Nabbaale, Juliet
collection PubMed
description BACKGROUND: Microalbuminuria is an early manifestation of kidney damage and independently predicts cardiovascular disease (CVD). Left ventricular hypertrophy (LVH) is also an early marker of cardiac manifestation of target organ damage among hypertensive patients. The prognostic significance of microalbuminuria and its correlation with left ventricular hypertrophy has not been extensively studied in African adult hypertensive populations. This study aimed at determining the prevalence of microalbuminuria, LVH in patients with microalbuminuria and the correlation between microalbuminuria and LVH among newly diagnosed black adult hypertensive patients attending a large outpatient hypertension clinic or admitted on the cardiology ward at Mulago national referral and teaching hospital and Uganda Heart Institute in Kampala, Uganda. METHODS: In this cross-sectional study, 256 newly diagnosed eligible black adult hypertensive patients attending the outpatient hypertension clinic or admitted on the cardiology ward at Mulago national referral and teaching hospital and the Uganda Heart Institute, Kampala Uganda were consecutively recruited over a period of 5 months. Data on socio-demographics, clinical and laboratory findings of the study participants was collected using a pre tested questionnaire. Two spot urine samples were collected to assess for microalbuminuria. Echocardiography (ECHO) was done to assess for the left ventricular mass index using the formula of Teicholz as evidence for early hypertensive heart disease. RESULTS: The mean age/standard deviation of the study participants was 54.3 ± 6.2 years with a female predominance (162, 63.3 %). The prevalence of microalbuminuria among newly diagnosed hypertensive patients was 39.5 %. The prevalence of LVH among patients with microalbuminuria was found to be 17 %. There was a positive correlation between microalbuminuria and left ventricular hypertrophy among the newly diagnosed adult hypertensive patients at Mulago Hospital (r = 0.185, p = 0.003). CONCLUSIONS: This study demonstrates that microalbuminuria is highly prevalent among newly diagnosed black hypertensive patients and in the presence of LVH. There is also a positive correlation between microalbuminuria and LVH among newly diagnosed hypertensive patients. Since it is a less costly and readily available test, it can be used to predict presence of LVH especially in resource limited settings where ECHO services are not readily available.
format Online
Article
Text
id pubmed-4434545
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-44345452015-05-19 Microalbuminuria and left ventricular hypertrophy among newly diagnosed black African hypertensive patients: a cross sectional study from a tertiary hospital in Uganda Nabbaale, Juliet Kibirige, Davis Ssekasanvu, Emmanuel Sebatta, Elias S Kayima, James Lwabi, Peter Kalyesubula, Robert BMC Res Notes Research Article BACKGROUND: Microalbuminuria is an early manifestation of kidney damage and independently predicts cardiovascular disease (CVD). Left ventricular hypertrophy (LVH) is also an early marker of cardiac manifestation of target organ damage among hypertensive patients. The prognostic significance of microalbuminuria and its correlation with left ventricular hypertrophy has not been extensively studied in African adult hypertensive populations. This study aimed at determining the prevalence of microalbuminuria, LVH in patients with microalbuminuria and the correlation between microalbuminuria and LVH among newly diagnosed black adult hypertensive patients attending a large outpatient hypertension clinic or admitted on the cardiology ward at Mulago national referral and teaching hospital and Uganda Heart Institute in Kampala, Uganda. METHODS: In this cross-sectional study, 256 newly diagnosed eligible black adult hypertensive patients attending the outpatient hypertension clinic or admitted on the cardiology ward at Mulago national referral and teaching hospital and the Uganda Heart Institute, Kampala Uganda were consecutively recruited over a period of 5 months. Data on socio-demographics, clinical and laboratory findings of the study participants was collected using a pre tested questionnaire. Two spot urine samples were collected to assess for microalbuminuria. Echocardiography (ECHO) was done to assess for the left ventricular mass index using the formula of Teicholz as evidence for early hypertensive heart disease. RESULTS: The mean age/standard deviation of the study participants was 54.3 ± 6.2 years with a female predominance (162, 63.3 %). The prevalence of microalbuminuria among newly diagnosed hypertensive patients was 39.5 %. The prevalence of LVH among patients with microalbuminuria was found to be 17 %. There was a positive correlation between microalbuminuria and left ventricular hypertrophy among the newly diagnosed adult hypertensive patients at Mulago Hospital (r = 0.185, p = 0.003). CONCLUSIONS: This study demonstrates that microalbuminuria is highly prevalent among newly diagnosed black hypertensive patients and in the presence of LVH. There is also a positive correlation between microalbuminuria and LVH among newly diagnosed hypertensive patients. Since it is a less costly and readily available test, it can be used to predict presence of LVH especially in resource limited settings where ECHO services are not readily available. BioMed Central 2015-05-14 /pmc/articles/PMC4434545/ /pubmed/25971452 http://dx.doi.org/10.1186/s13104-015-1156-2 Text en © Nabbaale et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Nabbaale, Juliet
Kibirige, Davis
Ssekasanvu, Emmanuel
Sebatta, Elias S
Kayima, James
Lwabi, Peter
Kalyesubula, Robert
Microalbuminuria and left ventricular hypertrophy among newly diagnosed black African hypertensive patients: a cross sectional study from a tertiary hospital in Uganda
title Microalbuminuria and left ventricular hypertrophy among newly diagnosed black African hypertensive patients: a cross sectional study from a tertiary hospital in Uganda
title_full Microalbuminuria and left ventricular hypertrophy among newly diagnosed black African hypertensive patients: a cross sectional study from a tertiary hospital in Uganda
title_fullStr Microalbuminuria and left ventricular hypertrophy among newly diagnosed black African hypertensive patients: a cross sectional study from a tertiary hospital in Uganda
title_full_unstemmed Microalbuminuria and left ventricular hypertrophy among newly diagnosed black African hypertensive patients: a cross sectional study from a tertiary hospital in Uganda
title_short Microalbuminuria and left ventricular hypertrophy among newly diagnosed black African hypertensive patients: a cross sectional study from a tertiary hospital in Uganda
title_sort microalbuminuria and left ventricular hypertrophy among newly diagnosed black african hypertensive patients: a cross sectional study from a tertiary hospital in uganda
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434545/
https://www.ncbi.nlm.nih.gov/pubmed/25971452
http://dx.doi.org/10.1186/s13104-015-1156-2
work_keys_str_mv AT nabbaalejuliet microalbuminuriaandleftventricularhypertrophyamongnewlydiagnosedblackafricanhypertensivepatientsacrosssectionalstudyfromatertiaryhospitalinuganda
AT kibirigedavis microalbuminuriaandleftventricularhypertrophyamongnewlydiagnosedblackafricanhypertensivepatientsacrosssectionalstudyfromatertiaryhospitalinuganda
AT ssekasanvuemmanuel microalbuminuriaandleftventricularhypertrophyamongnewlydiagnosedblackafricanhypertensivepatientsacrosssectionalstudyfromatertiaryhospitalinuganda
AT sebattaeliass microalbuminuriaandleftventricularhypertrophyamongnewlydiagnosedblackafricanhypertensivepatientsacrosssectionalstudyfromatertiaryhospitalinuganda
AT kayimajames microalbuminuriaandleftventricularhypertrophyamongnewlydiagnosedblackafricanhypertensivepatientsacrosssectionalstudyfromatertiaryhospitalinuganda
AT lwabipeter microalbuminuriaandleftventricularhypertrophyamongnewlydiagnosedblackafricanhypertensivepatientsacrosssectionalstudyfromatertiaryhospitalinuganda
AT kalyesubularobert microalbuminuriaandleftventricularhypertrophyamongnewlydiagnosedblackafricanhypertensivepatientsacrosssectionalstudyfromatertiaryhospitalinuganda