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Structural basis of human γ-secretase assembly

The four-component intramembrane protease γ-secretase is intricately linked to the development of Alzheimer’s disease. Despite recent structural advances, the transmembrane segments (TMs) of γ-secretase remain to be specifically assigned. Here we report a 3D structure of human γ-secretase at 4.32-Å...

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Detalles Bibliográficos
Autores principales:	Sun, Linfeng, Zhao, Lingyun, Yang, Guanghui, Yan, Chuangye, Zhou, Rui, Zhou, Xiaoyuan, Xie, Tian, Zhao, Yanyu, Wu, Shenjie, Li, Xueming, Shi, Yigong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2015
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434707/ https://www.ncbi.nlm.nih.gov/pubmed/25918421 http://dx.doi.org/10.1073/pnas.1506242112

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