Charge-mediated influence of the antibody variable domain on FcRn-dependent pharmacokinetics

Here, we investigated the influence of the variable fragment (Fv) of IgG antibodies on the binding to the neonatal Fc receptor (FcRn) as well as on FcRn-dependent pharmacokinetics (PK). FcRn plays a key role in IgG homeostasis, and specific manipulation in the crystallizable fragment (Fc) is known t...

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Detalles Bibliográficos
Autores principales: Schoch, Angela, Kettenberger, Hubert, Mundigl, Olaf, Winter, Gerhard, Engert, Julia, Heinrich, Julia, Emrich, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2015
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434771/
https://www.ncbi.nlm.nih.gov/pubmed/25918417
http://dx.doi.org/10.1073/pnas.1408766112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434771/
https://www.ncbi.nlm.nih.gov/pubmed/25918417
http://dx.doi.org/10.1073/pnas.1408766112

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