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Licochalcone A-induced human gastric cancer BGC-823 cells apoptosis by regulating ROS-mediated MAPKs and PI3K/AKT signaling pathways

Both phosphatidylinositol 3-kinase (PI3K)/AKT and mitogen activated protein kinase (MAPK) signaling cascades play an important role in cell proliferation, survival, angiogenesis, and metastasis of tumor cells. In the present report, we investigated the effects of licochalcone A (LA), a flavonoid ext...

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Detalles Bibliográficos
Autores principales: Hao, Wenjin, Yuan, Xuan, Yu, Lina, Gao, Caixia, Sun, Xiling, Wang, Dong, Zheng, Qiusheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434846/
https://www.ncbi.nlm.nih.gov/pubmed/25981581
http://dx.doi.org/10.1038/srep10336