Identification of potential HIV restriction factors by combining evolutionary genomic signatures with functional analyses

BACKGROUND: Known antiretroviral restriction factors are encoded by genes that are under positive selection pressure, induced during HIV-1 infection, up-regulated by interferons, and/or interact with viral proteins. To identify potential novel restriction factors, we performed genome-wide scans for...

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Detalles Bibliográficos
Autores principales: McLaren, Paul J, Gawanbacht, Ali, Pyndiah, Nitisha, Krapp, Christian, Hotter, Dominik, Kluge, Silvia F, Götz, Nicola, Heilmann, Jessica, Mack, Katharina, Sauter, Daniel, Thompson, Danielle, Perreaud, Jérémie, Rausell, Antonio, Munoz, Miguel, Ciuffi, Angela, Kirchhoff, Frank, Telenti, Amalio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434878/
https://www.ncbi.nlm.nih.gov/pubmed/25980612
http://dx.doi.org/10.1186/s12977-015-0165-5

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