SMAD3 deficiency promotes vessel wall remodeling, collagen fiber reorganization and leukocyte infiltration in an inflammatory abdominal aortic aneurysm mouse model

TGF-β signaling plays critical roles in the pathogenesis of aneurysms; however, it is still unclear whether its role is protective or destructive. In this study, we investigate the role of SMAD3 in the pathogenesis of calcium chloride (CaCl(2))-induced abdominal aortic aneurysms (AAA) in Smad3(−/−),...

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Detalles Bibliográficos
Autores principales: Dai, Xiaohua, Shen, Jianbin, Priyanka Annam, Neeraja, Jiang, Hong, Levi, Edi, Schworer, Charles M., Tromp, Gerard, Arora, Anandita, Higgins, Mary, Wang, Xiao-Fan, Yang, Maozhou, Li, Hui J., Zhang, Kezhong, Kuivaniemi, Helena, Li, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434993/
https://www.ncbi.nlm.nih.gov/pubmed/25985281
http://dx.doi.org/10.1038/srep10180

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