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EFFECT OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY ON VAGINAL Candida spp. ISOLATION IN HIV-INFECTED COMPARED TO HIV-UNINFECTED WOMEN
Vulvovaginal candidiasis (VVC) in HIV-infected women contributed to the impairment of their quality of life. The aim of this study was to evaluate the effect of highly active antiretroviral therapy (HAART) use on the vaginal Candida spp. isolation in HIV-infected compared to HIV-uninfected women. T...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Instituto de Medicina Tropical
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435017/ https://www.ncbi.nlm.nih.gov/pubmed/25923898 http://dx.doi.org/10.1590/S0036-46652015000200012 |
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author | ALCZUK, Silvia de Souza Dantas BONFIM-MENDONÇA, Patrícia de Souza ROCHA-BRISCHILIARI, Sheila Cristina SHINOBU-MESQUITA, Cristiane Suemi MARTINS, Helen Priscilla Rodrigues GIMENES, Fabrícia de ABREU, André Luelsdorf Pimenta CARVALHO, Maria Dalva de Barros PELLOSO, Sandra Marisa SVIDZINSKI, Terezinha Inez Estivalet CONSOLARO, Marcia Edilaine Lopes |
author_facet | ALCZUK, Silvia de Souza Dantas BONFIM-MENDONÇA, Patrícia de Souza ROCHA-BRISCHILIARI, Sheila Cristina SHINOBU-MESQUITA, Cristiane Suemi MARTINS, Helen Priscilla Rodrigues GIMENES, Fabrícia de ABREU, André Luelsdorf Pimenta CARVALHO, Maria Dalva de Barros PELLOSO, Sandra Marisa SVIDZINSKI, Terezinha Inez Estivalet CONSOLARO, Marcia Edilaine Lopes |
author_sort | ALCZUK, Silvia de Souza Dantas |
collection | PubMed |
description | Vulvovaginal candidiasis (VVC) in HIV-infected women contributed to the impairment of their quality of life. The aim of this study was to evaluate the effect of highly active antiretroviral therapy (HAART) use on the vaginal Candida spp. isolation in HIV-infected compared to HIV-uninfected women. This cross-sectional study included 178 HIV-infected (HIV group) and 200 HIV-uninfected women (control) that were studied at the Specialized Assistance Service (SAE) for sexually transmitted diseases (STD)/AIDS of the city of Maringá, Brazil, from April 1 to October 30, 2011. The yeasts were isolated and identified by phenotypic and molecular methods. The in vitro antifungal susceptibility to fluconazole, itraconazole, nystatin and amphotericin B was tested by the reference microdilution method. Higher frequencies of total vaginal Candida spp. isolation were found in the HIV-infected group than in the control group. However, both groups showed a similar frequency of colonization and VVC. Although C. albicans was the most frequent and sensitive to azolics and polyenes in both HIV-infected and uninfected women, the emerging resistance of C. glabrata to amphotericin B in the HIV-infected women was observed. Although higher frequency of vaginal Candida spp. isolation had been observed in the HIV-infected than in HIV-uninfected women, colonization and VVC showed similar frequency in both groups, indicating that HAART appears to protect against vaginal colonization and VVC. |
format | Online Article Text |
id | pubmed-4435017 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Instituto de Medicina Tropical |
record_format | MEDLINE/PubMed |
spelling | pubmed-44350172015-05-18 EFFECT OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY ON VAGINAL Candida spp. ISOLATION IN HIV-INFECTED COMPARED TO HIV-UNINFECTED WOMEN ALCZUK, Silvia de Souza Dantas BONFIM-MENDONÇA, Patrícia de Souza ROCHA-BRISCHILIARI, Sheila Cristina SHINOBU-MESQUITA, Cristiane Suemi MARTINS, Helen Priscilla Rodrigues GIMENES, Fabrícia de ABREU, André Luelsdorf Pimenta CARVALHO, Maria Dalva de Barros PELLOSO, Sandra Marisa SVIDZINSKI, Terezinha Inez Estivalet CONSOLARO, Marcia Edilaine Lopes Rev Inst Med Trop Sao Paulo Brief Communications Vulvovaginal candidiasis (VVC) in HIV-infected women contributed to the impairment of their quality of life. The aim of this study was to evaluate the effect of highly active antiretroviral therapy (HAART) use on the vaginal Candida spp. isolation in HIV-infected compared to HIV-uninfected women. This cross-sectional study included 178 HIV-infected (HIV group) and 200 HIV-uninfected women (control) that were studied at the Specialized Assistance Service (SAE) for sexually transmitted diseases (STD)/AIDS of the city of Maringá, Brazil, from April 1 to October 30, 2011. The yeasts were isolated and identified by phenotypic and molecular methods. The in vitro antifungal susceptibility to fluconazole, itraconazole, nystatin and amphotericin B was tested by the reference microdilution method. Higher frequencies of total vaginal Candida spp. isolation were found in the HIV-infected group than in the control group. However, both groups showed a similar frequency of colonization and VVC. Although C. albicans was the most frequent and sensitive to azolics and polyenes in both HIV-infected and uninfected women, the emerging resistance of C. glabrata to amphotericin B in the HIV-infected women was observed. Although higher frequency of vaginal Candida spp. isolation had been observed in the HIV-infected than in HIV-uninfected women, colonization and VVC showed similar frequency in both groups, indicating that HAART appears to protect against vaginal colonization and VVC. Instituto de Medicina Tropical 2015 /pmc/articles/PMC4435017/ /pubmed/25923898 http://dx.doi.org/10.1590/S0036-46652015000200012 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Brief Communications ALCZUK, Silvia de Souza Dantas BONFIM-MENDONÇA, Patrícia de Souza ROCHA-BRISCHILIARI, Sheila Cristina SHINOBU-MESQUITA, Cristiane Suemi MARTINS, Helen Priscilla Rodrigues GIMENES, Fabrícia de ABREU, André Luelsdorf Pimenta CARVALHO, Maria Dalva de Barros PELLOSO, Sandra Marisa SVIDZINSKI, Terezinha Inez Estivalet CONSOLARO, Marcia Edilaine Lopes EFFECT OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY ON VAGINAL Candida spp. ISOLATION IN HIV-INFECTED COMPARED TO HIV-UNINFECTED WOMEN |
title | EFFECT OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY ON VAGINAL
Candida spp. ISOLATION IN HIV-INFECTED COMPARED TO HIV-UNINFECTED
WOMEN |
title_full | EFFECT OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY ON VAGINAL
Candida spp. ISOLATION IN HIV-INFECTED COMPARED TO HIV-UNINFECTED
WOMEN |
title_fullStr | EFFECT OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY ON VAGINAL
Candida spp. ISOLATION IN HIV-INFECTED COMPARED TO HIV-UNINFECTED
WOMEN |
title_full_unstemmed | EFFECT OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY ON VAGINAL
Candida spp. ISOLATION IN HIV-INFECTED COMPARED TO HIV-UNINFECTED
WOMEN |
title_short | EFFECT OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY ON VAGINAL
Candida spp. ISOLATION IN HIV-INFECTED COMPARED TO HIV-UNINFECTED
WOMEN |
title_sort | effect of highly active antiretroviral therapy on vaginal
candida spp. isolation in hiv-infected compared to hiv-uninfected
women |
topic | Brief Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435017/ https://www.ncbi.nlm.nih.gov/pubmed/25923898 http://dx.doi.org/10.1590/S0036-46652015000200012 |
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