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Evaluation of inflammation-related genes polymorphisms in Mexican with Alzheimer’s disease: a pilot study
Amyloid peptide is able to promote the activation of microglia and astrocytes in Alzheimer’s disease (AD), and this stimulates the production of pro-inflammatory cytokines. Inflammation contributes to the process of neurodegeneration and therefore is a key factor in the development of AD. Some of th...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435067/ https://www.ncbi.nlm.nih.gov/pubmed/26041990 http://dx.doi.org/10.3389/fncel.2015.00148 |
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author | Toral-Rios, Danira Franco-Bocanegra, Diana Rosas-Carrasco, Oscar Mena-Barranco, Francisco Carvajal-García, Rosa Meraz-Ríos, Marco Antonio Campos-Peña, Victoria |
author_facet | Toral-Rios, Danira Franco-Bocanegra, Diana Rosas-Carrasco, Oscar Mena-Barranco, Francisco Carvajal-García, Rosa Meraz-Ríos, Marco Antonio Campos-Peña, Victoria |
author_sort | Toral-Rios, Danira |
collection | PubMed |
description | Amyloid peptide is able to promote the activation of microglia and astrocytes in Alzheimer’s disease (AD), and this stimulates the production of pro-inflammatory cytokines. Inflammation contributes to the process of neurodegeneration and therefore is a key factor in the development of AD. Some of the most important proteins involved in AD inflammation are: clusterin (CLU), complement receptor 1 (CR1), C reactive protein (CRP), tumor necrosis factor α (TNF-α), the interleukins 1α (IL-1α), 6 (IL-6), 10 (IL-10) and cyclooxygenase 2 (COX-2). In particular, COX-2 is encoded by the prostaglandin-endoperoxide synthase 2 gene (PTGS2). Since variations in the genes that encode these proteins may modify gene expression or function, it is important to investigate whether these variations may change the developing AD. The aim of this study was to determine whether the presence of polymorphisms in the genes encoding the aforementioned proteins is associated in Mexican patients with AD. Fourteen polymorphisms were genotyped in 96 subjects with AD and 100 controls; the differences in allele, genotype and haplotype frequencies were analyzed. Additionally, an ancestry analysis was conducted to exclude differences in genetic ancestry among groups as a confounding factor in the study. Significant differences in frequencies between AD and controls were found for the single-nucleotide polymorphism (SNP) rs20417 within the PTGS2 gene. Ancestry analysis revealed no significant differences in the ancestry of the compared groups, and the association was significant even after adjustment for ancestry and correction for multiple testing, which strengthens the validity of the results. We conclude that this polymorphism plays an important role in the development of the AD pathology and further studies are required, including their proteins. |
format | Online Article Text |
id | pubmed-4435067 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-44350672015-06-03 Evaluation of inflammation-related genes polymorphisms in Mexican with Alzheimer’s disease: a pilot study Toral-Rios, Danira Franco-Bocanegra, Diana Rosas-Carrasco, Oscar Mena-Barranco, Francisco Carvajal-García, Rosa Meraz-Ríos, Marco Antonio Campos-Peña, Victoria Front Cell Neurosci Neuroscience Amyloid peptide is able to promote the activation of microglia and astrocytes in Alzheimer’s disease (AD), and this stimulates the production of pro-inflammatory cytokines. Inflammation contributes to the process of neurodegeneration and therefore is a key factor in the development of AD. Some of the most important proteins involved in AD inflammation are: clusterin (CLU), complement receptor 1 (CR1), C reactive protein (CRP), tumor necrosis factor α (TNF-α), the interleukins 1α (IL-1α), 6 (IL-6), 10 (IL-10) and cyclooxygenase 2 (COX-2). In particular, COX-2 is encoded by the prostaglandin-endoperoxide synthase 2 gene (PTGS2). Since variations in the genes that encode these proteins may modify gene expression or function, it is important to investigate whether these variations may change the developing AD. The aim of this study was to determine whether the presence of polymorphisms in the genes encoding the aforementioned proteins is associated in Mexican patients with AD. Fourteen polymorphisms were genotyped in 96 subjects with AD and 100 controls; the differences in allele, genotype and haplotype frequencies were analyzed. Additionally, an ancestry analysis was conducted to exclude differences in genetic ancestry among groups as a confounding factor in the study. Significant differences in frequencies between AD and controls were found for the single-nucleotide polymorphism (SNP) rs20417 within the PTGS2 gene. Ancestry analysis revealed no significant differences in the ancestry of the compared groups, and the association was significant even after adjustment for ancestry and correction for multiple testing, which strengthens the validity of the results. We conclude that this polymorphism plays an important role in the development of the AD pathology and further studies are required, including their proteins. Frontiers Media S.A. 2015-05-18 /pmc/articles/PMC4435067/ /pubmed/26041990 http://dx.doi.org/10.3389/fncel.2015.00148 Text en Copyright © 2015 Toral-Rios, Franco-Bocanegra, Rosas-Carrasco, Mena-Barranco, Carvajal-García, Meraz-Ríos and Campos-Peña. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Toral-Rios, Danira Franco-Bocanegra, Diana Rosas-Carrasco, Oscar Mena-Barranco, Francisco Carvajal-García, Rosa Meraz-Ríos, Marco Antonio Campos-Peña, Victoria Evaluation of inflammation-related genes polymorphisms in Mexican with Alzheimer’s disease: a pilot study |
title | Evaluation of inflammation-related genes polymorphisms in Mexican with Alzheimer’s disease: a pilot study |
title_full | Evaluation of inflammation-related genes polymorphisms in Mexican with Alzheimer’s disease: a pilot study |
title_fullStr | Evaluation of inflammation-related genes polymorphisms in Mexican with Alzheimer’s disease: a pilot study |
title_full_unstemmed | Evaluation of inflammation-related genes polymorphisms in Mexican with Alzheimer’s disease: a pilot study |
title_short | Evaluation of inflammation-related genes polymorphisms in Mexican with Alzheimer’s disease: a pilot study |
title_sort | evaluation of inflammation-related genes polymorphisms in mexican with alzheimer’s disease: a pilot study |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435067/ https://www.ncbi.nlm.nih.gov/pubmed/26041990 http://dx.doi.org/10.3389/fncel.2015.00148 |
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