Engineering a Ca(++)-Sensitive (Bio)Sensor from the Pore-Module of a Potassium Channel

Signals recorded at the cell membrane are meaningful indicators of the physiological vs. pathological state of a cell and will become useful diagnostic elements in nanomedicine. In this project we present a coherent strategy for the design and fabrication of a bio-nano-sensor that monitors changes i...

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Autores principales: DiFrancesco, Mattia Lorenzo, Gazzarrini, Sabrina, Arrigoni, Cristina, Romani, Giulia, Thiel, Gerhard, Moroni, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435187/
https://www.ncbi.nlm.nih.gov/pubmed/25734643
http://dx.doi.org/10.3390/s150304913
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author DiFrancesco, Mattia Lorenzo
Gazzarrini, Sabrina
Arrigoni, Cristina
Romani, Giulia
Thiel, Gerhard
Moroni, Anna
author_facet DiFrancesco, Mattia Lorenzo
Gazzarrini, Sabrina
Arrigoni, Cristina
Romani, Giulia
Thiel, Gerhard
Moroni, Anna
author_sort DiFrancesco, Mattia Lorenzo
collection PubMed
description Signals recorded at the cell membrane are meaningful indicators of the physiological vs. pathological state of a cell and will become useful diagnostic elements in nanomedicine. In this project we present a coherent strategy for the design and fabrication of a bio-nano-sensor that monitors changes in intracellular cell calcium concentration and allows an easy read out by converting the calcium signal into an electrical current in the range of microampere that can be easily measured by conventional cell electrophysiology apparatus.
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spelling pubmed-44351872015-05-19 Engineering a Ca(++)-Sensitive (Bio)Sensor from the Pore-Module of a Potassium Channel DiFrancesco, Mattia Lorenzo Gazzarrini, Sabrina Arrigoni, Cristina Romani, Giulia Thiel, Gerhard Moroni, Anna Sensors (Basel) Article Signals recorded at the cell membrane are meaningful indicators of the physiological vs. pathological state of a cell and will become useful diagnostic elements in nanomedicine. In this project we present a coherent strategy for the design and fabrication of a bio-nano-sensor that monitors changes in intracellular cell calcium concentration and allows an easy read out by converting the calcium signal into an electrical current in the range of microampere that can be easily measured by conventional cell electrophysiology apparatus. MDPI 2015-02-27 /pmc/articles/PMC4435187/ /pubmed/25734643 http://dx.doi.org/10.3390/s150304913 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
DiFrancesco, Mattia Lorenzo
Gazzarrini, Sabrina
Arrigoni, Cristina
Romani, Giulia
Thiel, Gerhard
Moroni, Anna
Engineering a Ca(++)-Sensitive (Bio)Sensor from the Pore-Module of a Potassium Channel
title Engineering a Ca(++)-Sensitive (Bio)Sensor from the Pore-Module of a Potassium Channel
title_full Engineering a Ca(++)-Sensitive (Bio)Sensor from the Pore-Module of a Potassium Channel
title_fullStr Engineering a Ca(++)-Sensitive (Bio)Sensor from the Pore-Module of a Potassium Channel
title_full_unstemmed Engineering a Ca(++)-Sensitive (Bio)Sensor from the Pore-Module of a Potassium Channel
title_short Engineering a Ca(++)-Sensitive (Bio)Sensor from the Pore-Module of a Potassium Channel
title_sort engineering a ca(++)-sensitive (bio)sensor from the pore-module of a potassium channel
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435187/
https://www.ncbi.nlm.nih.gov/pubmed/25734643
http://dx.doi.org/10.3390/s150304913
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