Hematochezia Associated with Sevalamer-Induced Mucosal Injury

We present a case of a 61-year-old woman with end-stage renal disease (ESRD) who developed painless hematochezia following initiation of anticoagulation. Work-up revealed a large ulceration in the sigmoid colon, and histologic images revealed sevelamer crystals embedded in the colonic mucosa, consis...

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Detalles Bibliográficos
Autores principales: Chintamaneni, Preethi, Das, Rohit, Kuan, Shih-Fan, Kermanshahi, Taher R., Hashash, Jana G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American College of Gastroenterology 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435309/
https://www.ncbi.nlm.nih.gov/pubmed/26157856
http://dx.doi.org/10.14309/crj.2014.32
Descripción
Sumario:We present a case of a 61-year-old woman with end-stage renal disease (ESRD) who developed painless hematochezia following initiation of anticoagulation. Work-up revealed a large ulceration in the sigmoid colon, and histologic images revealed sevelamer crystals embedded in the colonic mucosa, consistent with sevelamer crystal-mediated injury. This is a novel cause of gastrointestinal hemorrhage that has not previously been described in the literature. Physicians should be aware of the potential for sevelamer-induced injury.

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