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Polymyositis Associated with Hepatitis B Virus Cirrhosis and Advanced Hepatocellular Carcinoma
Polymyositis (PM) is an inflammatory condition of skeletal muscle and is believed to be a paraneoplastic syndrome associated with various types of cancer. PM associated with chronic hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) is very rare. We report a case of advanced HCC with chr...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American College of Gastroenterology
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435311/ https://www.ncbi.nlm.nih.gov/pubmed/26157863 http://dx.doi.org/10.14309/crj.2014.39 |
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author | Thanapirom, Kessarin Aniwan, Satimai Treeprasertsuk, Sombat |
author_facet | Thanapirom, Kessarin Aniwan, Satimai Treeprasertsuk, Sombat |
author_sort | Thanapirom, Kessarin |
collection | PubMed |
description | Polymyositis (PM) is an inflammatory condition of skeletal muscle and is believed to be a paraneoplastic syndrome associated with various types of cancer. PM associated with chronic hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) is very rare. We report a case of advanced HCC with chronic HBV cirrhosis that presented with proximal muscle weakness. Further investigation showed elevation of muscle enzymes, myopathic pattern of electromyography (EMG), and evidence of myositis compatible with PM. Lamivudine and 1 mg/kg of oral prednisolone were given. Two sessions of transcatheter arterial chemoembolization (TACE) were performed and sorafenib was started. Muscle enzymes normalized after 6 weeks of treatment. Unfortunately, 5 months after treatment, patient was readmitted and died of severe bacterial pneumonia. |
format | Online Article Text |
id | pubmed-4435311 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | American College of Gastroenterology |
record_format | MEDLINE/PubMed |
spelling | pubmed-44353112015-07-08 Polymyositis Associated with Hepatitis B Virus Cirrhosis and Advanced Hepatocellular Carcinoma Thanapirom, Kessarin Aniwan, Satimai Treeprasertsuk, Sombat ACG Case Rep J Case Report Polymyositis (PM) is an inflammatory condition of skeletal muscle and is believed to be a paraneoplastic syndrome associated with various types of cancer. PM associated with chronic hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) is very rare. We report a case of advanced HCC with chronic HBV cirrhosis that presented with proximal muscle weakness. Further investigation showed elevation of muscle enzymes, myopathic pattern of electromyography (EMG), and evidence of myositis compatible with PM. Lamivudine and 1 mg/kg of oral prednisolone were given. Two sessions of transcatheter arterial chemoembolization (TACE) were performed and sorafenib was started. Muscle enzymes normalized after 6 weeks of treatment. Unfortunately, 5 months after treatment, patient was readmitted and died of severe bacterial pneumonia. American College of Gastroenterology 2014-04-04 /pmc/articles/PMC4435311/ /pubmed/26157863 http://dx.doi.org/10.14309/crj.2014.39 Text en Copyright © Thanapirom et al. This is an open-access article. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/ |
spellingShingle | Case Report Thanapirom, Kessarin Aniwan, Satimai Treeprasertsuk, Sombat Polymyositis Associated with Hepatitis B Virus Cirrhosis and Advanced Hepatocellular Carcinoma |
title | Polymyositis Associated with Hepatitis B Virus Cirrhosis and Advanced Hepatocellular Carcinoma |
title_full | Polymyositis Associated with Hepatitis B Virus Cirrhosis and Advanced Hepatocellular Carcinoma |
title_fullStr | Polymyositis Associated with Hepatitis B Virus Cirrhosis and Advanced Hepatocellular Carcinoma |
title_full_unstemmed | Polymyositis Associated with Hepatitis B Virus Cirrhosis and Advanced Hepatocellular Carcinoma |
title_short | Polymyositis Associated with Hepatitis B Virus Cirrhosis and Advanced Hepatocellular Carcinoma |
title_sort | polymyositis associated with hepatitis b virus cirrhosis and advanced hepatocellular carcinoma |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435311/ https://www.ncbi.nlm.nih.gov/pubmed/26157863 http://dx.doi.org/10.14309/crj.2014.39 |
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