Treatment of Leptomeningeal Carcinomatosis in a Patient With Metastatic Cholangiocarcinoma

A 49-year-old woman with cholangiocarcinoma metastatic to the lungs presented with new-onset unrelenting headaches. A lumbar puncture revealed malignant cells consistent with leptomeningeal metastasis from her cholangiocarcinoma. Magnetic resonance imaging (MRI) of the brain revealed leptomeningeal...

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Detalles Bibliográficos
Autores principales: Jacobs, Ramon E.A., McNeill, Katharine, Volpicelli, Frank M., Warltier, Karin, Iturrate, Eduardo, Okamura, Charles, Adler, Nicole, Smith, Joshua, Sigmund, Alana, Mednick, Aron, Wertheimer, Benjamin, Hochman, Katherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American College of Gastroenterology 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435345/
https://www.ncbi.nlm.nih.gov/pubmed/26157901
http://dx.doi.org/10.14309/crj.2014.78
Descripción
Sumario:A 49-year-old woman with cholangiocarcinoma metastatic to the lungs presented with new-onset unrelenting headaches. A lumbar puncture revealed malignant cells consistent with leptomeningeal metastasis from her cholangiocarcinoma. Magnetic resonance imaging (MRI) of the brain revealed leptomeningeal enhancement. An intrathecal (IT) catheter was placed and IT chemotherapy was initiated with methotrexate. Her case is notable for the rarity of cholangiocarcinoma spread to the leptomeninges, the use of IT chemotherapy with cytologic and potentially symptomatic response, and a possible survival benefit in comparison to previously reported cases of leptomeningeal carcinomatosis secondary to cholangiocarcinoma.

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