Osteopetrosis: A New Cause of Upper Gastrointestinal Bleeding

Osteopetrosis is a genetic disorder of bone remodeling caused by osteoclast dysfunction. Clinical features include short stature, frequent fractures, and recurrent infections. Abnormal bone obliterates the marrow cavity, resulting pancytopenia and extramedullary hematopoiesis in the liver and spleen...

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Detalles Bibliográficos
Autores principales: Katz, Kristina N., Shafqet, Muhammad A., Rampertab, S. Devi, Pooran, Nakechand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American College of Gastroenterology 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435355/
https://www.ncbi.nlm.nih.gov/pubmed/26157903
http://dx.doi.org/10.14309/crj.2014.80
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author Katz, Kristina N.
Shafqet, Muhammad A.
Rampertab, S. Devi
Pooran, Nakechand
author_facet Katz, Kristina N.
Shafqet, Muhammad A.
Rampertab, S. Devi
Pooran, Nakechand
author_sort Katz, Kristina N.
collection PubMed
description Osteopetrosis is a genetic disorder of bone remodeling caused by osteoclast dysfunction. Clinical features include short stature, frequent fractures, and recurrent infections. Abnormal bone obliterates the marrow cavity, resulting pancytopenia and extramedullary hematopoiesis in the liver and spleen. The splenomegaly can lead to left-sided portal hypertension. We report the second case of osteopetrosis-induced portal hypertension and the first case of upper gastrointestinal bleeding in a 52-year-old woman with osteopetrosis.
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spelling pubmed-44353552015-07-08 Osteopetrosis: A New Cause of Upper Gastrointestinal Bleeding Katz, Kristina N. Shafqet, Muhammad A. Rampertab, S. Devi Pooran, Nakechand ACG Case Rep J Case Report Osteopetrosis is a genetic disorder of bone remodeling caused by osteoclast dysfunction. Clinical features include short stature, frequent fractures, and recurrent infections. Abnormal bone obliterates the marrow cavity, resulting pancytopenia and extramedullary hematopoiesis in the liver and spleen. The splenomegaly can lead to left-sided portal hypertension. We report the second case of osteopetrosis-induced portal hypertension and the first case of upper gastrointestinal bleeding in a 52-year-old woman with osteopetrosis. American College of Gastroenterology 2014-10-10 /pmc/articles/PMC4435355/ /pubmed/26157903 http://dx.doi.org/10.14309/crj.2014.80 Text en Copyright © Katz et al. This is an open-access article. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Case Report
Katz, Kristina N.
Shafqet, Muhammad A.
Rampertab, S. Devi
Pooran, Nakechand
Osteopetrosis: A New Cause of Upper Gastrointestinal Bleeding
title Osteopetrosis: A New Cause of Upper Gastrointestinal Bleeding
title_full Osteopetrosis: A New Cause of Upper Gastrointestinal Bleeding
title_fullStr Osteopetrosis: A New Cause of Upper Gastrointestinal Bleeding
title_full_unstemmed Osteopetrosis: A New Cause of Upper Gastrointestinal Bleeding
title_short Osteopetrosis: A New Cause of Upper Gastrointestinal Bleeding
title_sort osteopetrosis: a new cause of upper gastrointestinal bleeding
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435355/
https://www.ncbi.nlm.nih.gov/pubmed/26157903
http://dx.doi.org/10.14309/crj.2014.80
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AT rampertabsdevi osteopetrosisanewcauseofuppergastrointestinalbleeding
AT poorannakechand osteopetrosisanewcauseofuppergastrointestinalbleeding

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