Caustic Injury and Stricture of the Esophagus After Long-Term Phenytoin Use

A 50-year-old man with a history of epilepsy controlled with phenytoin presented for evaluation of dysphagia. History revealed the patient was taking his phenytoin daily without water. Barium esophagram showed severe stricturing of the mid-esophagus. Upper endoscopy revealed diffuse gross mucosal ab...

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Detalles Bibliográficos
Autores principales: Nelson, Kirbylee K., Clayton, Steven B., Champeaux, Anne L., Feldman, John C., Richter, Joel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American College of Gastroenterology 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435379/
https://www.ncbi.nlm.nih.gov/pubmed/26157921
http://dx.doi.org/10.14309/crj.2015.12
Descripción
Sumario:A 50-year-old man with a history of epilepsy controlled with phenytoin presented for evaluation of dysphagia. History revealed the patient was taking his phenytoin daily without water. Barium esophagram showed severe stricturing of the mid-esophagus. Upper endoscopy revealed diffuse gross mucosal abnormality with a thick stricture and occasional exudate. Biopsies were consistent with a drug-induced injury with lymphocytic infiltration and epithelial cell necrosis.

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