Caustic Injury and Stricture of the Esophagus After Long-Term Phenytoin Use

A 50-year-old man with a history of epilepsy controlled with phenytoin presented for evaluation of dysphagia. History revealed the patient was taking his phenytoin daily without water. Barium esophagram showed severe stricturing of the mid-esophagus. Upper endoscopy revealed diffuse gross mucosal ab...

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Autores principales: Nelson, Kirbylee K., Clayton, Steven B., Champeaux, Anne L., Feldman, John C., Richter, Joel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American College of Gastroenterology 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435379/
https://www.ncbi.nlm.nih.gov/pubmed/26157921
http://dx.doi.org/10.14309/crj.2015.12
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author Nelson, Kirbylee K.
Clayton, Steven B.
Champeaux, Anne L.
Feldman, John C.
Richter, Joel E.
author_facet Nelson, Kirbylee K.
Clayton, Steven B.
Champeaux, Anne L.
Feldman, John C.
Richter, Joel E.
author_sort Nelson, Kirbylee K.
collection PubMed
description A 50-year-old man with a history of epilepsy controlled with phenytoin presented for evaluation of dysphagia. History revealed the patient was taking his phenytoin daily without water. Barium esophagram showed severe stricturing of the mid-esophagus. Upper endoscopy revealed diffuse gross mucosal abnormality with a thick stricture and occasional exudate. Biopsies were consistent with a drug-induced injury with lymphocytic infiltration and epithelial cell necrosis.
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spelling pubmed-44353792015-07-08 Caustic Injury and Stricture of the Esophagus After Long-Term Phenytoin Use Nelson, Kirbylee K. Clayton, Steven B. Champeaux, Anne L. Feldman, John C. Richter, Joel E. ACG Case Rep J Case Report A 50-year-old man with a history of epilepsy controlled with phenytoin presented for evaluation of dysphagia. History revealed the patient was taking his phenytoin daily without water. Barium esophagram showed severe stricturing of the mid-esophagus. Upper endoscopy revealed diffuse gross mucosal abnormality with a thick stricture and occasional exudate. Biopsies were consistent with a drug-induced injury with lymphocytic infiltration and epithelial cell necrosis. American College of Gastroenterology 2015-01-16 /pmc/articles/PMC4435379/ /pubmed/26157921 http://dx.doi.org/10.14309/crj.2015.12 Text en Copyright © Nelson et al. This is an open-access article. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Case Report
Nelson, Kirbylee K.
Clayton, Steven B.
Champeaux, Anne L.
Feldman, John C.
Richter, Joel E.
Caustic Injury and Stricture of the Esophagus After Long-Term Phenytoin Use
title Caustic Injury and Stricture of the Esophagus After Long-Term Phenytoin Use
title_full Caustic Injury and Stricture of the Esophagus After Long-Term Phenytoin Use
title_fullStr Caustic Injury and Stricture of the Esophagus After Long-Term Phenytoin Use
title_full_unstemmed Caustic Injury and Stricture of the Esophagus After Long-Term Phenytoin Use
title_short Caustic Injury and Stricture of the Esophagus After Long-Term Phenytoin Use
title_sort caustic injury and stricture of the esophagus after long-term phenytoin use
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435379/
https://www.ncbi.nlm.nih.gov/pubmed/26157921
http://dx.doi.org/10.14309/crj.2015.12
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