Anakinra Hepatotoxicity in a Patient With Adult-Onset Still's Disease

We report a 46-year-old white woman with adult-onset Still's disease (AOSD) treated with anakinra, a IL-1B receptor antagonist. Within weeks, her liver enzymes deteriorated; subsequent cessation and rechallenge confirmed anakinra-related drug-induced liver injury (DILI). Although AOSD has been...

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Autores principales: Ahmed, Osman, Brahmania, Mayur, Alsahafi, Majid, Alkhowaiter, Saad, Erb, Sig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American College of Gastroenterology 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435404/
https://www.ncbi.nlm.nih.gov/pubmed/26157954
http://dx.doi.org/10.14309/crj.2015.45
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author Ahmed, Osman
Brahmania, Mayur
Alsahafi, Majid
Alkhowaiter, Saad
Erb, Sig
author_facet Ahmed, Osman
Brahmania, Mayur
Alsahafi, Majid
Alkhowaiter, Saad
Erb, Sig
author_sort Ahmed, Osman
collection PubMed
description We report a 46-year-old white woman with adult-onset Still's disease (AOSD) treated with anakinra, a IL-1B receptor antagonist. Within weeks, her liver enzymes deteriorated; subsequent cessation and rechallenge confirmed anakinra-related drug-induced liver injury (DILI). Although AOSD has been associated with liver involvement, little is known about the hepatotoxicity of anakinra. Heightened awareness by gastroenterologists and hepatologists is warranted.
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spelling pubmed-44354042015-07-08 Anakinra Hepatotoxicity in a Patient With Adult-Onset Still's Disease Ahmed, Osman Brahmania, Mayur Alsahafi, Majid Alkhowaiter, Saad Erb, Sig ACG Case Rep J Case Report We report a 46-year-old white woman with adult-onset Still's disease (AOSD) treated with anakinra, a IL-1B receptor antagonist. Within weeks, her liver enzymes deteriorated; subsequent cessation and rechallenge confirmed anakinra-related drug-induced liver injury (DILI). Although AOSD has been associated with liver involvement, little is known about the hepatotoxicity of anakinra. Heightened awareness by gastroenterologists and hepatologists is warranted. American College of Gastroenterology 2015-04-10 /pmc/articles/PMC4435404/ /pubmed/26157954 http://dx.doi.org/10.14309/crj.2015.45 Text en Copyright © Ahmed et al. This is an open-access article. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.
spellingShingle Case Report
Ahmed, Osman
Brahmania, Mayur
Alsahafi, Majid
Alkhowaiter, Saad
Erb, Sig
Anakinra Hepatotoxicity in a Patient With Adult-Onset Still's Disease
title Anakinra Hepatotoxicity in a Patient With Adult-Onset Still's Disease
title_full Anakinra Hepatotoxicity in a Patient With Adult-Onset Still's Disease
title_fullStr Anakinra Hepatotoxicity in a Patient With Adult-Onset Still's Disease
title_full_unstemmed Anakinra Hepatotoxicity in a Patient With Adult-Onset Still's Disease
title_short Anakinra Hepatotoxicity in a Patient With Adult-Onset Still's Disease
title_sort anakinra hepatotoxicity in a patient with adult-onset still's disease
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435404/
https://www.ncbi.nlm.nih.gov/pubmed/26157954
http://dx.doi.org/10.14309/crj.2015.45
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