Alpha Fetoprotein-Secreting Gastric Cancer in the Setting of Chronic Hepatitis B: The Role of Endoscopy

Alpha-fetoprotein (AFP) is a common tumor marker for hepatocellular carcinoma (HCC). We report a unique case of an AFP-producing gastric cancer in an elderly man with known chronic hepatitis B (HBV) and a markedly elevated AFP. Thorough diagnostic imaging failed to reveal a HCC, but a gastric adenoc...

Descripción completa

Detalles Bibliográficos
Autores principales: Ip, Stephen, Schaeffer, David F., Yoshida, Eric M., Kwan, WC Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American College of Gastroenterology 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435407/
https://www.ncbi.nlm.nih.gov/pubmed/26157947
http://dx.doi.org/10.14309/crj.2015.38
_version_ 1782371918933917696
author Ip, Stephen
Schaeffer, David F.
Yoshida, Eric M.
Kwan, WC Peter
author_facet Ip, Stephen
Schaeffer, David F.
Yoshida, Eric M.
Kwan, WC Peter
author_sort Ip, Stephen
collection PubMed
description Alpha-fetoprotein (AFP) is a common tumor marker for hepatocellular carcinoma (HCC). We report a unique case of an AFP-producing gastric cancer in an elderly man with known chronic hepatitis B (HBV) and a markedly elevated AFP. Thorough diagnostic imaging failed to reveal a HCC, but a gastric adenocarcinoma was found on endoscopy. After successful resection, the serum AFP normalized. On histopathologic examination, the cancer demonstrated focal positive staining for AFP, in keeping with a hepatoid gastric adenocarcinoma. Endoscopy should be considered in clinical situations where increased serum AFP is detected but no HCC is found.
format Online
Article
Text
id pubmed-4435407
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher American College of Gastroenterology
record_format MEDLINE/PubMed
spelling pubmed-44354072015-07-08 Alpha Fetoprotein-Secreting Gastric Cancer in the Setting of Chronic Hepatitis B: The Role of Endoscopy Ip, Stephen Schaeffer, David F. Yoshida, Eric M. Kwan, WC Peter ACG Case Rep J Case Report Alpha-fetoprotein (AFP) is a common tumor marker for hepatocellular carcinoma (HCC). We report a unique case of an AFP-producing gastric cancer in an elderly man with known chronic hepatitis B (HBV) and a markedly elevated AFP. Thorough diagnostic imaging failed to reveal a HCC, but a gastric adenocarcinoma was found on endoscopy. After successful resection, the serum AFP normalized. On histopathologic examination, the cancer demonstrated focal positive staining for AFP, in keeping with a hepatoid gastric adenocarcinoma. Endoscopy should be considered in clinical situations where increased serum AFP is detected but no HCC is found. American College of Gastroenterology 2015-04-10 /pmc/articles/PMC4435407/ /pubmed/26157947 http://dx.doi.org/10.14309/crj.2015.38 Text en Copyright © Ip et al. This is an open-access article. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.
spellingShingle Case Report
Ip, Stephen
Schaeffer, David F.
Yoshida, Eric M.
Kwan, WC Peter
Alpha Fetoprotein-Secreting Gastric Cancer in the Setting of Chronic Hepatitis B: The Role of Endoscopy
title Alpha Fetoprotein-Secreting Gastric Cancer in the Setting of Chronic Hepatitis B: The Role of Endoscopy
title_full Alpha Fetoprotein-Secreting Gastric Cancer in the Setting of Chronic Hepatitis B: The Role of Endoscopy
title_fullStr Alpha Fetoprotein-Secreting Gastric Cancer in the Setting of Chronic Hepatitis B: The Role of Endoscopy
title_full_unstemmed Alpha Fetoprotein-Secreting Gastric Cancer in the Setting of Chronic Hepatitis B: The Role of Endoscopy
title_short Alpha Fetoprotein-Secreting Gastric Cancer in the Setting of Chronic Hepatitis B: The Role of Endoscopy
title_sort alpha fetoprotein-secreting gastric cancer in the setting of chronic hepatitis b: the role of endoscopy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435407/
https://www.ncbi.nlm.nih.gov/pubmed/26157947
http://dx.doi.org/10.14309/crj.2015.38
work_keys_str_mv AT ipstephen alphafetoproteinsecretinggastriccancerinthesettingofchronichepatitisbtheroleofendoscopy
AT schaefferdavidf alphafetoproteinsecretinggastriccancerinthesettingofchronichepatitisbtheroleofendoscopy
AT yoshidaericm alphafetoproteinsecretinggastriccancerinthesettingofchronichepatitisbtheroleofendoscopy
AT kwanwcpeter alphafetoproteinsecretinggastriccancerinthesettingofchronichepatitisbtheroleofendoscopy

Ejemplares similares