ANT2-defective fibroblasts exhibit normal mitochondrial bioenergetics

Adenine nucleotide translocase 2 (ANT2) transports glycolytic ATP across the inner mitochondrial membrane. Patients with ANT2 deletion were recently reported. We aimed at characterizing mitochondrial functions in ANT2-defective fibroblasts. In spite of ANT2 expression in fibroblasts, we observed no...

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Autores principales: Prabhu, Dolly, Goldstein, Amy C., El-Khoury, Riyad, Rak, Malgorzata, Edmunds, Lia, Rustin, Pierre, Vockley, Jerry, Schiff, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435574/
https://www.ncbi.nlm.nih.gov/pubmed/26000237
http://dx.doi.org/10.1016/j.ymgmr.2015.03.005
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author Prabhu, Dolly
Goldstein, Amy C.
El-Khoury, Riyad
Rak, Malgorzata
Edmunds, Lia
Rustin, Pierre
Vockley, Jerry
Schiff, Manuel
author_facet Prabhu, Dolly
Goldstein, Amy C.
El-Khoury, Riyad
Rak, Malgorzata
Edmunds, Lia
Rustin, Pierre
Vockley, Jerry
Schiff, Manuel
author_sort Prabhu, Dolly
collection PubMed
description Adenine nucleotide translocase 2 (ANT2) transports glycolytic ATP across the inner mitochondrial membrane. Patients with ANT2 deletion were recently reported. We aimed at characterizing mitochondrial functions in ANT2-defective fibroblasts. In spite of ANT2 expression in fibroblasts, we observed no difference between ANT2-defective and control fibroblasts for mitochondrial respiration, respiratory chain activities, mitochondrial membrane potential and intracellular ATP levels. This indicates that ANT2 insufficiency does not alter fibroblast basal mitochondrial bioenergetics.
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spelling pubmed-44355742016-03-02 ANT2-defective fibroblasts exhibit normal mitochondrial bioenergetics Prabhu, Dolly Goldstein, Amy C. El-Khoury, Riyad Rak, Malgorzata Edmunds, Lia Rustin, Pierre Vockley, Jerry Schiff, Manuel Mol Genet Metab Rep Short Communication Adenine nucleotide translocase 2 (ANT2) transports glycolytic ATP across the inner mitochondrial membrane. Patients with ANT2 deletion were recently reported. We aimed at characterizing mitochondrial functions in ANT2-defective fibroblasts. In spite of ANT2 expression in fibroblasts, we observed no difference between ANT2-defective and control fibroblasts for mitochondrial respiration, respiratory chain activities, mitochondrial membrane potential and intracellular ATP levels. This indicates that ANT2 insufficiency does not alter fibroblast basal mitochondrial bioenergetics. Elsevier 2015-04-02 /pmc/articles/PMC4435574/ /pubmed/26000237 http://dx.doi.org/10.1016/j.ymgmr.2015.03.005 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Short Communication
Prabhu, Dolly
Goldstein, Amy C.
El-Khoury, Riyad
Rak, Malgorzata
Edmunds, Lia
Rustin, Pierre
Vockley, Jerry
Schiff, Manuel
ANT2-defective fibroblasts exhibit normal mitochondrial bioenergetics
title ANT2-defective fibroblasts exhibit normal mitochondrial bioenergetics
title_full ANT2-defective fibroblasts exhibit normal mitochondrial bioenergetics
title_fullStr ANT2-defective fibroblasts exhibit normal mitochondrial bioenergetics
title_full_unstemmed ANT2-defective fibroblasts exhibit normal mitochondrial bioenergetics
title_short ANT2-defective fibroblasts exhibit normal mitochondrial bioenergetics
title_sort ant2-defective fibroblasts exhibit normal mitochondrial bioenergetics
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435574/
https://www.ncbi.nlm.nih.gov/pubmed/26000237
http://dx.doi.org/10.1016/j.ymgmr.2015.03.005
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