Conformal Nanopatterning of Extracellular Matrix Proteins onto Topographically Complex Surfaces

We report a method for conformal nanopatterning of extracellular matrix proteins onto engineered surfaces independent of underlying microtopography. This enables fibronectin, laminin, and other proteins to be applied to biomaterial surfaces in complex geometries inaccessible using traditional soft l...

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Detalles Bibliográficos
Autores principales: Sun, Yan, Jallerat, Quentin, Szymanski, John M., Feinberg, Adam W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435615/
https://www.ncbi.nlm.nih.gov/pubmed/25506720
http://dx.doi.org/10.1038/nmeth.3210
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author Sun, Yan
Jallerat, Quentin
Szymanski, John M.
Feinberg, Adam W.
author_facet Sun, Yan
Jallerat, Quentin
Szymanski, John M.
Feinberg, Adam W.
author_sort Sun, Yan
collection PubMed
description We report a method for conformal nanopatterning of extracellular matrix proteins onto engineered surfaces independent of underlying microtopography. This enables fibronectin, laminin, and other proteins to be applied to biomaterial surfaces in complex geometries inaccessible using traditional soft lithography techniques. Engineering combinatorial surfaces that integrate topographical and biochemical micropatterns enhances control of the biotic-abiotic interface, used here to understand cardiomyocyte response to competing physical and chemical cues in the microenvironment.
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spelling pubmed-44356152015-08-01 Conformal Nanopatterning of Extracellular Matrix Proteins onto Topographically Complex Surfaces Sun, Yan Jallerat, Quentin Szymanski, John M. Feinberg, Adam W. Nat Methods Article We report a method for conformal nanopatterning of extracellular matrix proteins onto engineered surfaces independent of underlying microtopography. This enables fibronectin, laminin, and other proteins to be applied to biomaterial surfaces in complex geometries inaccessible using traditional soft lithography techniques. Engineering combinatorial surfaces that integrate topographical and biochemical micropatterns enhances control of the biotic-abiotic interface, used here to understand cardiomyocyte response to competing physical and chemical cues in the microenvironment. 2014-12-15 2015-02 /pmc/articles/PMC4435615/ /pubmed/25506720 http://dx.doi.org/10.1038/nmeth.3210 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Sun, Yan
Jallerat, Quentin
Szymanski, John M.
Feinberg, Adam W.
Conformal Nanopatterning of Extracellular Matrix Proteins onto Topographically Complex Surfaces
title Conformal Nanopatterning of Extracellular Matrix Proteins onto Topographically Complex Surfaces
title_full Conformal Nanopatterning of Extracellular Matrix Proteins onto Topographically Complex Surfaces
title_fullStr Conformal Nanopatterning of Extracellular Matrix Proteins onto Topographically Complex Surfaces
title_full_unstemmed Conformal Nanopatterning of Extracellular Matrix Proteins onto Topographically Complex Surfaces
title_short Conformal Nanopatterning of Extracellular Matrix Proteins onto Topographically Complex Surfaces
title_sort conformal nanopatterning of extracellular matrix proteins onto topographically complex surfaces
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435615/
https://www.ncbi.nlm.nih.gov/pubmed/25506720
http://dx.doi.org/10.1038/nmeth.3210
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