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Tiam1-Rac1 Axis Promotes Activation of p38 MAP Kinase in the Development of Diabetic Retinopathy: Evidence for a Requisite Role for Protein Palmitoylation

BACKGROUND/AIMS: Evidence in multiple tissues, including retina, suggests generation of reactive oxygen species (ROS) and the ensuing oxidative stress as triggers for mitochondrial defects and cell apoptosis. We recently reported novel roles for Tiam1-Rac1-Nox2 axis in retinal mitochondrial dysfunct...

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Detalles Bibliográficos
Autores principales:	Veluthakal, Rajakrishnan, Kumar, Binit, Mohammad, Ghulam, Kowluru, Anjaneyulu, Kowluru, Renu A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435616/ https://www.ncbi.nlm.nih.gov/pubmed/25967961 http://dx.doi.org/10.1159/000374065

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