Sarcoidosis with bone involvement mimicking metastatic disease at (18)F-FDG PET/CT: problem solving by diffusion whole-body MRI

Bone involvement has been reported in 1–13% of patients with sarcoidosis. Both 18F-fluorodeoxyglucose ((18)F-FDG) Positron Emission Tomography/Computed Tomography (PET/CT) and conventional magnetic resonance imaging (MRI) are sensitive in detecting sarcoidosis bone lesions, but are not always reliab...

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Detalles Bibliográficos
Autores principales: Conte, Giorgio, Zugni, Fabio, Colleoni, Marco, Renne, Giuseppe, Bellomi, Massimo, Petralia, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cancer Intelligence 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435754/
https://www.ncbi.nlm.nih.gov/pubmed/26015806
http://dx.doi.org/10.3332/ecancer.2015.537
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author Conte, Giorgio
Zugni, Fabio
Colleoni, Marco
Renne, Giuseppe
Bellomi, Massimo
Petralia, Giuseppe
author_facet Conte, Giorgio
Zugni, Fabio
Colleoni, Marco
Renne, Giuseppe
Bellomi, Massimo
Petralia, Giuseppe
author_sort Conte, Giorgio
collection PubMed
description Bone involvement has been reported in 1–13% of patients with sarcoidosis. Both 18F-fluorodeoxyglucose ((18)F-FDG) Positron Emission Tomography/Computed Tomography (PET/CT) and conventional magnetic resonance imaging (MRI) are sensitive in detecting sarcoidosis bone lesions, but are not always reliable in differentiating sarcoidosis bone lesions from metastatic disease, thus often requiring bone biopsy. We describe the use of diffusion whole-body MRI for bone assessment in a patient with breast cancer and sarcoidosis, presenting with bone marrow lesions mimicking metastatic disease at (18)F-FDG PET/CT. In our case, diffusion whole-body MRI represented a useful tool for bone assessment and overcame the limitation of (18)F-FDG PET/CT in discriminating inflammatory bone marrow involvement from metastatic disease.
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spelling pubmed-44357542015-05-26 Sarcoidosis with bone involvement mimicking metastatic disease at (18)F-FDG PET/CT: problem solving by diffusion whole-body MRI Conte, Giorgio Zugni, Fabio Colleoni, Marco Renne, Giuseppe Bellomi, Massimo Petralia, Giuseppe Ecancermedicalscience Review Bone involvement has been reported in 1–13% of patients with sarcoidosis. Both 18F-fluorodeoxyglucose ((18)F-FDG) Positron Emission Tomography/Computed Tomography (PET/CT) and conventional magnetic resonance imaging (MRI) are sensitive in detecting sarcoidosis bone lesions, but are not always reliable in differentiating sarcoidosis bone lesions from metastatic disease, thus often requiring bone biopsy. We describe the use of diffusion whole-body MRI for bone assessment in a patient with breast cancer and sarcoidosis, presenting with bone marrow lesions mimicking metastatic disease at (18)F-FDG PET/CT. In our case, diffusion whole-body MRI represented a useful tool for bone assessment and overcame the limitation of (18)F-FDG PET/CT in discriminating inflammatory bone marrow involvement from metastatic disease. Cancer Intelligence 2015-05-07 /pmc/articles/PMC4435754/ /pubmed/26015806 http://dx.doi.org/10.3332/ecancer.2015.537 Text en © the authors; licensee ecancermedicalscience. http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Conte, Giorgio
Zugni, Fabio
Colleoni, Marco
Renne, Giuseppe
Bellomi, Massimo
Petralia, Giuseppe
Sarcoidosis with bone involvement mimicking metastatic disease at (18)F-FDG PET/CT: problem solving by diffusion whole-body MRI
title Sarcoidosis with bone involvement mimicking metastatic disease at (18)F-FDG PET/CT: problem solving by diffusion whole-body MRI
title_full Sarcoidosis with bone involvement mimicking metastatic disease at (18)F-FDG PET/CT: problem solving by diffusion whole-body MRI
title_fullStr Sarcoidosis with bone involvement mimicking metastatic disease at (18)F-FDG PET/CT: problem solving by diffusion whole-body MRI
title_full_unstemmed Sarcoidosis with bone involvement mimicking metastatic disease at (18)F-FDG PET/CT: problem solving by diffusion whole-body MRI
title_short Sarcoidosis with bone involvement mimicking metastatic disease at (18)F-FDG PET/CT: problem solving by diffusion whole-body MRI
title_sort sarcoidosis with bone involvement mimicking metastatic disease at (18)f-fdg pet/ct: problem solving by diffusion whole-body mri
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435754/
https://www.ncbi.nlm.nih.gov/pubmed/26015806
http://dx.doi.org/10.3332/ecancer.2015.537
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