Dengue Virus NS Proteins Inhibit RIG-I/MAVS Signaling by Blocking TBK1/IRF3 Phosphorylation: Dengue Virus Serotype 1 NS4A Is a Unique Interferon-Regulating Virulence Determinant

Dengue virus (DENV) replication is inhibited by the prior addition of type I interferon or by RIG-I agonists that elicit RIG-I/MAVS/TBK1/IRF3-dependent protective responses. DENV infection of primary human endothelial cells (ECs) results in a rapid increase in viral titer, which suggests that DENV i...

Descripción completa

Detalles Bibliográficos
Autores principales: Dalrymple, Nadine A., Cimica, Velasco, Mackow, Erich R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436066/
https://www.ncbi.nlm.nih.gov/pubmed/25968648
http://dx.doi.org/10.1128/mBio.00553-15

Ejemplares similares

Ejemplares similares