Target Mechanism-Based Whole-Cell Screening Identifies Bortezomib as an Inhibitor of Caseinolytic Protease in Mycobacteria

A novel type of antibacterial screening method, a target mechanism-based whole-cell screening method, was developed to combine the advantages of target mechanism- and whole-cell-based approaches. A mycobacterial reporter strain with a synthetic phenotype for caseinolytic protease (ClpP1P2) activity...

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Detalles Bibliográficos
Autores principales: Moreira, Wilfried, Ngan, Grace J. Y., Low, Jian Liang, Poulsen, Anders, Chia, Brian C. S., Ang, Melgious J. Y., Yap, Amelia, Fulwood, Justina, Lakshmanan, Umayal, Lim, Jolander, Khoo, Audrey Y. T., Flotow, Horst, Hill, Jeffrey, Raju, Ravikiran M., Rubin, Eric J., Dick, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436076/
https://www.ncbi.nlm.nih.gov/pubmed/25944857
http://dx.doi.org/10.1128/mBio.00253-15

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