Genetic background of skin barrier dysfunction in the pathogenesis of psoriasis vulgaris

Psoriasis is a common inflammatory skin disease. It is known to be a complex condition with multifactorial mode of inheritance, however the associations between particular pathogenic pathways remain unclear. A novel report on the pathogenesis of psoriasis has recently included the genetic determinat...

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Autores principales: Stawczyk-Macieja, Marta, Szczerkowska-Dobosz, Aneta, Rębała, Krzysztof, Purzycka-Bohdan, Dorota
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2015
Materias:
Review Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436234/
https://www.ncbi.nlm.nih.gov/pubmed/26015782
http://dx.doi.org/10.5114/pdia.2014.44003
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author Stawczyk-Macieja, Marta
Szczerkowska-Dobosz, Aneta
Rębała, Krzysztof
Purzycka-Bohdan, Dorota
author_facet Stawczyk-Macieja, Marta
Szczerkowska-Dobosz, Aneta
Rębała, Krzysztof
Purzycka-Bohdan, Dorota
author_sort Stawczyk-Macieja, Marta
collection PubMed
description Psoriasis is a common inflammatory skin disease. It is known to be a complex condition with multifactorial mode of inheritance, however the associations between particular pathogenic pathways remain unclear. A novel report on the pathogenesis of psoriasis has recently included the genetic determination of the skin barrier dysfunction. In this paper, we focus on specific genetic variants associated with formation of the epidermal barrier and their role in the complex pathogenesis of the disease.
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spelling pubmed-44362342015-05-26 Genetic background of skin barrier dysfunction in the pathogenesis of psoriasis vulgaris Stawczyk-Macieja, Marta Szczerkowska-Dobosz, Aneta Rębała, Krzysztof Purzycka-Bohdan, Dorota Postepy Dermatol Alergol Review Paper Psoriasis is a common inflammatory skin disease. It is known to be a complex condition with multifactorial mode of inheritance, however the associations between particular pathogenic pathways remain unclear. A novel report on the pathogenesis of psoriasis has recently included the genetic determination of the skin barrier dysfunction. In this paper, we focus on specific genetic variants associated with formation of the epidermal barrier and their role in the complex pathogenesis of the disease. Termedia Publishing House 2015-03-30 2015-04 /pmc/articles/PMC4436234/ /pubmed/26015782 http://dx.doi.org/10.5114/pdia.2014.44003 Text en Copyright © 2015 Termedia http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Paper
Stawczyk-Macieja, Marta
Szczerkowska-Dobosz, Aneta
Rębała, Krzysztof
Purzycka-Bohdan, Dorota
Genetic background of skin barrier dysfunction in the pathogenesis of psoriasis vulgaris
title Genetic background of skin barrier dysfunction in the pathogenesis of psoriasis vulgaris
title_full Genetic background of skin barrier dysfunction in the pathogenesis of psoriasis vulgaris
title_fullStr Genetic background of skin barrier dysfunction in the pathogenesis of psoriasis vulgaris
title_full_unstemmed Genetic background of skin barrier dysfunction in the pathogenesis of psoriasis vulgaris
title_short Genetic background of skin barrier dysfunction in the pathogenesis of psoriasis vulgaris
title_sort genetic background of skin barrier dysfunction in the pathogenesis of psoriasis vulgaris
topic Review Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436234/
https://www.ncbi.nlm.nih.gov/pubmed/26015782
http://dx.doi.org/10.5114/pdia.2014.44003
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