Impaired Telomere Maintenance and Decreased Canonical WNT Signaling but Normal Ribosome Biogenesis in Induced Pluripotent Stem Cells from X-Linked Dyskeratosis Congenita Patients

Dyskeratosis congenita (DC) is an inherited bone marrow failure syndrome characterized by the presence of short telomeres at presentation. Mutations in ten different genes, whose products are involved in the telomere maintenance pathway, have been shown to cause DC. The X-linked form is the most com...

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Detalles Bibliográficos
Autores principales: Gu, Bai-Wei, Apicella, Marisa, Mills, Jason, Fan, Jian-Meng, Reeves, Dara A., French, Deborah, Podsakoff, Gregory M., Bessler, Monica, Mason, Philip J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436374/
https://www.ncbi.nlm.nih.gov/pubmed/25992652
http://dx.doi.org/10.1371/journal.pone.0127414

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436374/
https://www.ncbi.nlm.nih.gov/pubmed/25992652
http://dx.doi.org/10.1371/journal.pone.0127414

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