Thiosemicarbazone p-Substituted Acetophenone Derivatives Promote the Loss of Mitochondrial Δψ, GSH Depletion, and Death in K562 Cells

A series of thiosemicarbazone (TSC) p-substituted acetophenone derivatives were synthesized and chemically characterized. The p-substituents appended to the phenyl group of the TSC structures were hydrogen, fluor, chlorine, methyl, and nitro, producing compounds named TSC-H, TSC-F, TSC-Cl, TSC-Me, a...

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Detalles Bibliográficos
Autores principales: Pessoto, Felipe S., Yokomizo, Cesar H., Prieto, Tatiana, Fernandes, Cleverton S., Silva, Alan P., Kaiser, Carlos R., Basso, Ernani A., Nantes, Iseli L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436459/
https://www.ncbi.nlm.nih.gov/pubmed/26075034
http://dx.doi.org/10.1155/2015/394367

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