Advanced maternal age in Indian children with thyroid dysgenesis

A retrospective review of medical records of 80 children with thyroid dysgenesis (TD) was conducted to determine the association of gender and maternal age with TD. The study subjects were attending the Pediatric Endocrinology Clinic of our hospital which is a large tertiary care Multispecialty Pediatric Center located in Chandigarh, Northwest India. There were no gender differences (boys to girls’ ratio 1:1). Mean maternal age of 25.87 ± 4.17 yrs (range 19–35 yrs) was significantly higher as compared to the mean maternal age of 23.87 ± 3.34 yrs (range 18–39 yrs) of a reference group (p < 0.0001). Odds of being older than 30 yrs were higher in mothers of children with TD as compared to mothers of normal children (OR 3.23; 95% CI: 1.54–6.44) (p-value 0.0003). In conclusion, our data shows that advanced maternal age is more prevalent in children with TD.