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Acute lower motor neuron syndrome and spinal cord gray matter hyperintensities in HIV infection

OBJECTIVE: To describe a novel manifestation of lower motor neuron disease in patients with well-controlled HIV infection. METHODS: A retrospective study was performed to identify HIV-positive individuals with acute, painful lower motor neuron diseases. RESULTS: Six patients were identified with HIV...

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Autores principales: Bogoch, Isaac I., Wilson, Michael R., Chad, David A., Venna, Nagagopal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436596/
https://www.ncbi.nlm.nih.gov/pubmed/26015990
http://dx.doi.org/10.1212/NXI.0000000000000113
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author Bogoch, Isaac I.
Wilson, Michael R.
Chad, David A.
Venna, Nagagopal
author_facet Bogoch, Isaac I.
Wilson, Michael R.
Chad, David A.
Venna, Nagagopal
author_sort Bogoch, Isaac I.
collection PubMed
description OBJECTIVE: To describe a novel manifestation of lower motor neuron disease in patients with well-controlled HIV infection. METHODS: A retrospective study was performed to identify HIV-positive individuals with acute, painful lower motor neuron diseases. RESULTS: Six patients were identified with HIV and lower motor neuron disease. Two patients met the inclusion criteria of well-controlled, chronic HIV infection and an acute, painful, unilateral lower motor neuron paralytic syndrome affecting the distal portion of the upper limb. These patients had segmental T2-hyperintense lesions in the central gray matter of the cervical spinal cord on MRI. One patient stabilized and the second patient improved with immunomodulatory therapy. CONCLUSIONS: This newly described syndrome expands the clinical spectrum of lower motor neuron diseases in HIV.
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spelling pubmed-44365962015-05-26 Acute lower motor neuron syndrome and spinal cord gray matter hyperintensities in HIV infection Bogoch, Isaac I. Wilson, Michael R. Chad, David A. Venna, Nagagopal Neurol Neuroimmunol Neuroinflamm Article OBJECTIVE: To describe a novel manifestation of lower motor neuron disease in patients with well-controlled HIV infection. METHODS: A retrospective study was performed to identify HIV-positive individuals with acute, painful lower motor neuron diseases. RESULTS: Six patients were identified with HIV and lower motor neuron disease. Two patients met the inclusion criteria of well-controlled, chronic HIV infection and an acute, painful, unilateral lower motor neuron paralytic syndrome affecting the distal portion of the upper limb. These patients had segmental T2-hyperintense lesions in the central gray matter of the cervical spinal cord on MRI. One patient stabilized and the second patient improved with immunomodulatory therapy. CONCLUSIONS: This newly described syndrome expands the clinical spectrum of lower motor neuron diseases in HIV. Lippincott Williams & Wilkins 2015-05-14 /pmc/articles/PMC4436596/ /pubmed/26015990 http://dx.doi.org/10.1212/NXI.0000000000000113 Text en © 2015 American Academy of Neurology This is an open access article distributed under the terms of the Creative Commons Attribution-Noncommercial No Derivative 4.0 License, which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially.
spellingShingle Article
Bogoch, Isaac I.
Wilson, Michael R.
Chad, David A.
Venna, Nagagopal
Acute lower motor neuron syndrome and spinal cord gray matter hyperintensities in HIV infection
title Acute lower motor neuron syndrome and spinal cord gray matter hyperintensities in HIV infection
title_full Acute lower motor neuron syndrome and spinal cord gray matter hyperintensities in HIV infection
title_fullStr Acute lower motor neuron syndrome and spinal cord gray matter hyperintensities in HIV infection
title_full_unstemmed Acute lower motor neuron syndrome and spinal cord gray matter hyperintensities in HIV infection
title_short Acute lower motor neuron syndrome and spinal cord gray matter hyperintensities in HIV infection
title_sort acute lower motor neuron syndrome and spinal cord gray matter hyperintensities in hiv infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436596/
https://www.ncbi.nlm.nih.gov/pubmed/26015990
http://dx.doi.org/10.1212/NXI.0000000000000113
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