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A fatal outcome due to pulmonary hemorrhage following Russell’s viper bite

Russell’s viper (RV) envenomation causes local effects, coagulopathy, thrombosis, rhabdomyolysis, acute kidney injury, and neurological manifestations. Although coagulopathy and endothelial destruction causing local and mucosal surface bleeding is known, isolated severe pulmonary hemorrhage is not c...

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Autores principales: Palangasinghe, Dhammika R., Weerakkody, Ranga M., Dalpatadu, Chamila G., Gnanathasan, Christeine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Saudi Medical Journal 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436764/
https://www.ncbi.nlm.nih.gov/pubmed/25935188
http://dx.doi.org/10.15537/smj.2015.5.10691
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author Palangasinghe, Dhammika R.
Weerakkody, Ranga M.
Dalpatadu, Chamila G.
Gnanathasan, Christeine A.
author_facet Palangasinghe, Dhammika R.
Weerakkody, Ranga M.
Dalpatadu, Chamila G.
Gnanathasan, Christeine A.
author_sort Palangasinghe, Dhammika R.
collection PubMed
description Russell’s viper (RV) envenomation causes local effects, coagulopathy, thrombosis, rhabdomyolysis, acute kidney injury, and neurological manifestations. Although coagulopathy and endothelial destruction causing local and mucosal surface bleeding is known, isolated severe pulmonary hemorrhage is not commonly reported. We report a previously healthy 18-year-old male who had bilateral severe pulmonary hemorrhages, which resulted in a fatal outcome following RV bite. This diagnosis was supported by persistent alveolar shadows, with minimum improvement despite hemodialysis without heparin, mixed acidosis and endotracheal tube bleeding. Other bleeding manifestations were absent. Polyvalent antivenom was administered in lieu of prolonged whole blood clotting time. Thrombocytopenia and mildly deranged clotting parameters were noted. Pulmonary hemorrhages were significant enough to require transfusion. This case highlights the importance of suspecting pulmonary hemorrhages in patients with alveolar shadows and desaturation following RV bite despite the absence of other bleeding manifestations in light of failure of optimum therapy including hemodialysis.
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spelling pubmed-44367642015-05-20 A fatal outcome due to pulmonary hemorrhage following Russell’s viper bite Palangasinghe, Dhammika R. Weerakkody, Ranga M. Dalpatadu, Chamila G. Gnanathasan, Christeine A. Saudi Med J Case Report Russell’s viper (RV) envenomation causes local effects, coagulopathy, thrombosis, rhabdomyolysis, acute kidney injury, and neurological manifestations. Although coagulopathy and endothelial destruction causing local and mucosal surface bleeding is known, isolated severe pulmonary hemorrhage is not commonly reported. We report a previously healthy 18-year-old male who had bilateral severe pulmonary hemorrhages, which resulted in a fatal outcome following RV bite. This diagnosis was supported by persistent alveolar shadows, with minimum improvement despite hemodialysis without heparin, mixed acidosis and endotracheal tube bleeding. Other bleeding manifestations were absent. Polyvalent antivenom was administered in lieu of prolonged whole blood clotting time. Thrombocytopenia and mildly deranged clotting parameters were noted. Pulmonary hemorrhages were significant enough to require transfusion. This case highlights the importance of suspecting pulmonary hemorrhages in patients with alveolar shadows and desaturation following RV bite despite the absence of other bleeding manifestations in light of failure of optimum therapy including hemodialysis. Saudi Medical Journal 2015-05 /pmc/articles/PMC4436764/ /pubmed/25935188 http://dx.doi.org/10.15537/smj.2015.5.10691 Text en Copyright: © Saudi Medical Journal http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Palangasinghe, Dhammika R.
Weerakkody, Ranga M.
Dalpatadu, Chamila G.
Gnanathasan, Christeine A.
A fatal outcome due to pulmonary hemorrhage following Russell’s viper bite
title A fatal outcome due to pulmonary hemorrhage following Russell’s viper bite
title_full A fatal outcome due to pulmonary hemorrhage following Russell’s viper bite
title_fullStr A fatal outcome due to pulmonary hemorrhage following Russell’s viper bite
title_full_unstemmed A fatal outcome due to pulmonary hemorrhage following Russell’s viper bite
title_short A fatal outcome due to pulmonary hemorrhage following Russell’s viper bite
title_sort fatal outcome due to pulmonary hemorrhage following russell’s viper bite
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436764/
https://www.ncbi.nlm.nih.gov/pubmed/25935188
http://dx.doi.org/10.15537/smj.2015.5.10691
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