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The FHA domain determines Drosophila Chk2/Mnk localization to key mitotic structures and is essential for early embryonic DNA damage responses

DNA damage responses, including mitotic centrosome inactivation, cell-cycle delay in mitosis, and nuclear dropping from embryo cortex, maintain genome integrity in syncytial Drosophila embryos. A conserved signaling kinase, Chk2, known as Mnk/Loki, is essential for the responses. Here we demonstrate...

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Detalles Bibliográficos
Autores principales:	Takada, Saeko, Collins, Eric R., Kurahashi, Kayo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436828/ https://www.ncbi.nlm.nih.gov/pubmed/25808488 http://dx.doi.org/10.1091/mbc.E14-07-1238

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