Cargando…

The FHA domain determines Drosophila Chk2/Mnk localization to key mitotic structures and is essential for early embryonic DNA damage responses

DNA damage responses, including mitotic centrosome inactivation, cell-cycle delay in mitosis, and nuclear dropping from embryo cortex, maintain genome integrity in syncytial Drosophila embryos. A conserved signaling kinase, Chk2, known as Mnk/Loki, is essential for the responses. Here we demonstrate...

Descripción completa

Detalles Bibliográficos
Autores principales:	Takada, Saeko, Collins, Eric R., Kurahashi, Kayo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436828/ https://www.ncbi.nlm.nih.gov/pubmed/25808488 http://dx.doi.org/10.1091/mbc.E14-07-1238

Ejemplares similares

The FHA and BRCT domains recognize ADP-ribosylation during DNA damage response
por: Li, Mo, et al.
Publicado: (2013)

Structural Insights into the Recognition of Phosphopeptide by the FHA Domain of Kanadaptin
por: Xu, Qingping, et al.
Publicado: (2014)

MNK1 and MNK2 expression in the human dorsal root and trigeminal ganglion
por: Shiers, Stephanie, et al.
Publicado: (2023)

Versatility in phospho-dependent molecular recognition of the XRCC1 and XRCC4 DNA-damage scaffolds by aprataxin-family FHA domains
por: Cherry, Amy L., et al.
Publicado: (2015)

The FHA domain protein ArnA functions as a global DNA damage response repressor in the hyperthermophilic archaeon Saccharolobus islandicus
por: Jiang, Zhichao, et al.
Publicado: (2023)

Phosphopeptide interactions of the Nbs1 N-terminal FHA-BRCT1/2 domains
por: Kim, Kyungmin, et al.
Publicado: (2021)

MNK1 and MNK2 mediate adverse effects of high-fat feeding in distinct ways
por: Moore, C. E. J., et al.
Publicado: (2016)

Regulation of Budding Yeast Mating-Type Switching Donor Preference by the FHA Domain of Fkh1
por: Li, Jin, et al.
Publicado: (2012)

Chk2 prevents mitotic exit when the majority of kinetochores are unattached
por: Petsalaki, Eleni, et al.
Publicado: (2014)

MNK Proteins as Therapeutic Targets in Leukemia
por: Mazewski, Candice, et al.
Publicado: (2023)

Angiogenic Factor with G-patch and FHA Domain 1 (AGGF1) Expression in Human Vascular Lesions
por: Zhan, Maosheng, et al.
Publicado: (2016)

Prenatal phenotype of PNKP-related primary microcephaly associated with variants affecting both the FHA and phosphatase domain
por: Neuser, Sonja, et al.
Publicado: (2021)

Microcephalin and pericentrin regulate mitotic entry via centrosome-associated Chk1
por: Tibelius, Alexandra, et al.
Publicado: (2009)

An FHA domain–mediated protein interaction network of Rad53 reveals its role in polarized cell growth
por: Smolka, Marcus B., et al.
Publicado: (2006)

Phosphorylation-Dependent Interactions between Crb2 and Chk1 Are Essential for DNA Damage Checkpoint
por: Qu, Meng, et al.
Publicado: (2012)

Increased expression of MNK1b, the spliced isoform of MNK1, predicts poor prognosis and is associated with triple-negative breast cancer
por: Pinto-Díez, Celia, et al.
Publicado: (2018)

Specific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNK
por: Ali, Ammar A. E., et al.
Publicado: (2009)

KA1-targeted regulatory domain mutations activate Chk1 in the absence of DNA damage
por: Gong, Eun-Yeung, et al.
Publicado: (2015)

Role of MAPK/MNK1 signaling in virus replication
por: Kumar, Ram, et al.
Publicado: (2018)

MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma
por: Ke, Xin-Yu, et al.
Publicado: (2021)

Ubiquitination of the DNA-damage checkpoint kinase CHK1 by TRAF4 is required for CHK1 activation
por: Yu, Xinfang, et al.
Publicado: (2020)

Pharmacological inactivation of CHK1 and WEE1 induces mitotic catastrophe in nasopharyngeal carcinoma cells
por: Mak, Joyce P.Y., et al.
Publicado: (2015)

Forkhead-associated (FHA) Domain Containing ABC Transporter Rv1747 Is Positively Regulated by Ser/Thr Phosphorylation in Mycobacterium tuberculosis
por: Spivey, Vicky L., et al.
Publicado: (2011)

A Mutation in the FHA Domain of Coprinus cinereus Nbs1 Leads to Spo11-Independent Meiotic Recombination and Chromosome Segregation
por: Crown, K. Nicole, et al.
Publicado: (2013)

Targeting AGGF1 (angiogenic factor with G patch and FHA domains 1) for Blocking Neointimal Formation After Vascular Injury
por: Yao, Yufeng, et al.
Publicado: (2017)

High Expression of Angiogenic Factor with G-Patch and FHA Domain1 (AGGF1) Predicts Poor Prognosis in Gastric Cancer
por: Yao, Han-Hui, et al.
Publicado: (2017)

Type VI secretion system-associated FHA domain protein TagH regulates the hemolytic activity and virulence of Vibrio cholerae
por: Wang, Guangli, et al.
Publicado: (2022)

ATM/Chk2 and ATR/Chk1 Pathways Respond to DNA Damage Induced by Movento(®) 240SC and Envidor(®) 240SC Keto-Enol Insecticides in the Germarium of Drosophila melanogaster
por: González-Marín, Berenyce, et al.
Publicado: (2023)

Conserved Omp85 lid-lock structure and substrate recognition in FhaC
por: Maier, Timm, et al.
Publicado: (2015)

Chk1, Chk2, is the amplifier on?
por: Dove, Alan W.
Publicado: (2001)

CHK2 kinase in the DNA damage response and beyond
por: Zannini, Laura, et al.
Publicado: (2014)

A role for pre-mNK cells in tumor progression
por: Rosinsky, Carolyn, et al.
Publicado: (2016)

Probing the Anticancer Action of Novel Ferrocene Analogues of MNK Inhibitors
por: Sansook, Supojjanee, et al.
Publicado: (2018)

Oncogenic MNK signalling regulates the metastasis suppressor NDRG1
por: Tian, Shuye, et al.
Publicado: (2017)

JAK2-CHK2 signaling safeguards the integrity of the mitotic spindle assembly checkpoint and genome stability
por: Chowdhury, Md Al Nayem, et al.
Publicado: (2022)

Domain-specific functions of Stardust in Drosophila embryonic development
por: Koch, Leonie, et al.
Publicado: (2016)

Erratum to: Genetic Screen for Genes Involved in Chk2 Signaling in Drosophila
por: Park, Suk-Young, et al.
Publicado: (2014)

Fha Interaction with Phosphothreonine of TssL Activates Type VI Secretion in Agrobacterium tumefaciens
por: Lin, Jer-Sheng, et al.
Publicado: (2014)

Characterization of the APLF FHA–XRCC1 phosphopeptide interaction and its structural and functional implications
por: Kim, Kyungmin, et al.
Publicado: (2017)

Identification of Ser/Thr kinase and Forkhead Associated Domains in Mycobacterium ulcerans: Characterization of Novel Association between Protein Kinase Q and MupFHA
por: Arora, Gunjan, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_jqj2rfst97nr4m80fg5l9mqsmf