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Multisite phosphorylation of the NDC80 complex gradually tunes its microtubule-binding affinity

Microtubule (MT) attachment to kinetochores is vitally important for cell division, but how these interactions are controlled by phosphorylation is not well known. We used quantitative approaches in vitro combined with molecular dynamics simulations to examine phosphoregulation of the NDC80 complex,...

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Detalles Bibliográficos
Autores principales:	Zaytsev, Anatoly V., Mick, Jeanne E., Maslennikov, Evgeny, Nikashin, Boris, DeLuca, Jennifer G., Grishchuk, Ekaterina L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436829/ https://www.ncbi.nlm.nih.gov/pubmed/25808492 http://dx.doi.org/10.1091/mbc.E14-11-1539

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