Preventing farnesylation of the dynein adaptor Spindly contributes to the mitotic defects caused by farnesyltransferase inhibitors

The clinical interest in farnesyltransferase inhibitors (FTIs) makes it important to understand how these compounds affect cellular processes involving farnesylated proteins. Mitotic abnormalities observed after treatment with FTIs have so far been attributed to defects in the farnesylation of the o...

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Detalles Bibliográficos
Autores principales: Holland, Andrew J., Reis, Rita M., Niessen, Sherry, Pereira, Cláudia, Andres, Douglas A., Spielmann, H. Peter, Cleveland, Don W., Desai, Arshad, Gassmann, Reto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436830/
https://www.ncbi.nlm.nih.gov/pubmed/25808490
http://dx.doi.org/10.1091/mbc.E14-11-1560

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436830/
https://www.ncbi.nlm.nih.gov/pubmed/25808490
http://dx.doi.org/10.1091/mbc.E14-11-1560

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