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Regeneration of the retina: toward stem cell therapy for degenerative retinal diseases

Degenerative retinal diseases affect millions of people worldwide, which can lead to the loss of vision. However, therapeutic approaches that can reverse this process are limited. Recent efforts have allowed the possibility of the stem cell-based regeneration of retinal cells and repair of injured r...

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Detalles Bibliográficos
Autores principales: Jeon, Sohee, Oh, Il-Hoan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436854/
https://www.ncbi.nlm.nih.gov/pubmed/25560700
http://dx.doi.org/10.5483/BMBRep.2015.48.4.276
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author Jeon, Sohee
Oh, Il-Hoan
author_facet Jeon, Sohee
Oh, Il-Hoan
author_sort Jeon, Sohee
collection PubMed
description Degenerative retinal diseases affect millions of people worldwide, which can lead to the loss of vision. However, therapeutic approaches that can reverse this process are limited. Recent efforts have allowed the possibility of the stem cell-based regeneration of retinal cells and repair of injured retinal tissues. Although the direct differentiation of pluripotent stem cells into terminally differentiated photoreceptor cells comprises one approach, a series of studies revealed the intrinsic regenerative potential of the retina using endogenous retinal stem cells. Muller glial cells, ciliary pigment epithelial cells, and retinal pigment epithelial cells are candidates for such retinal stem cells that can differentiate into multiple types of retinal cells and be integrated into injured or developing retina. In this review, we explore our current understanding of the cellular identity of these candidate retinal stem cells and their therapeutic potential for cell therapy against degenerative retinal diseases. [BMB Reports 2015; 48(4): 193-199]
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spelling pubmed-44368542015-05-20 Regeneration of the retina: toward stem cell therapy for degenerative retinal diseases Jeon, Sohee Oh, Il-Hoan BMB Rep Invited Mini Review Degenerative retinal diseases affect millions of people worldwide, which can lead to the loss of vision. However, therapeutic approaches that can reverse this process are limited. Recent efforts have allowed the possibility of the stem cell-based regeneration of retinal cells and repair of injured retinal tissues. Although the direct differentiation of pluripotent stem cells into terminally differentiated photoreceptor cells comprises one approach, a series of studies revealed the intrinsic regenerative potential of the retina using endogenous retinal stem cells. Muller glial cells, ciliary pigment epithelial cells, and retinal pigment epithelial cells are candidates for such retinal stem cells that can differentiate into multiple types of retinal cells and be integrated into injured or developing retina. In this review, we explore our current understanding of the cellular identity of these candidate retinal stem cells and their therapeutic potential for cell therapy against degenerative retinal diseases. [BMB Reports 2015; 48(4): 193-199] Korean Society for Biochemistry and Molecular Biology 2015-04 /pmc/articles/PMC4436854/ /pubmed/25560700 http://dx.doi.org/10.5483/BMBRep.2015.48.4.276 Text en Copyright © 2015, Korean Society for Biochemistry and Molecular Biology http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (-g0http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Invited Mini Review
Jeon, Sohee
Oh, Il-Hoan
Regeneration of the retina: toward stem cell therapy for degenerative retinal diseases
title Regeneration of the retina: toward stem cell therapy for degenerative retinal diseases
title_full Regeneration of the retina: toward stem cell therapy for degenerative retinal diseases
title_fullStr Regeneration of the retina: toward stem cell therapy for degenerative retinal diseases
title_full_unstemmed Regeneration of the retina: toward stem cell therapy for degenerative retinal diseases
title_short Regeneration of the retina: toward stem cell therapy for degenerative retinal diseases
title_sort regeneration of the retina: toward stem cell therapy for degenerative retinal diseases
topic Invited Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436854/
https://www.ncbi.nlm.nih.gov/pubmed/25560700
http://dx.doi.org/10.5483/BMBRep.2015.48.4.276
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