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Tumor size and prognosis in patients with Wilms tumor

OBJECTIVE: Investigate the relationship of the tumor volume after preoperative chemotherapy (TVAPQ) and before preoperative chemotherapy (TVBPQ) with overall survival at two and at five years, and lifetime. METHODS: Our sample consisted of consecutive patients evaluated in the period from 1989 to 20...

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Autores principales: Provenzi, Valentina Oliveira, Rosa, Rafael Fabiano Machado, Rosa, Rosana Cardoso Manique, Roehe, Adriana Vial, dos Santos, Pedro Paulo Albino, Faulhaber, Fabrízia Rennó Sodero, de Oliveira, Ceres Andréia Vieira, Zen, Paulo Ricardo Gazzola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade de Pediatria de São Paulo 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436960/
https://www.ncbi.nlm.nih.gov/pubmed/25623730
http://dx.doi.org/10.1016/j.rpped.2014.05.003
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author Provenzi, Valentina Oliveira
Rosa, Rafael Fabiano Machado
Rosa, Rosana Cardoso Manique
Roehe, Adriana Vial
dos Santos, Pedro Paulo Albino
Faulhaber, Fabrízia Rennó Sodero
de Oliveira, Ceres Andréia Vieira
Zen, Paulo Ricardo Gazzola
author_facet Provenzi, Valentina Oliveira
Rosa, Rafael Fabiano Machado
Rosa, Rosana Cardoso Manique
Roehe, Adriana Vial
dos Santos, Pedro Paulo Albino
Faulhaber, Fabrízia Rennó Sodero
de Oliveira, Ceres Andréia Vieira
Zen, Paulo Ricardo Gazzola
author_sort Provenzi, Valentina Oliveira
collection PubMed
description OBJECTIVE: Investigate the relationship of the tumor volume after preoperative chemotherapy (TVAPQ) and before preoperative chemotherapy (TVBPQ) with overall survival at two and at five years, and lifetime. METHODS: Our sample consisted of consecutive patients evaluated in the period from 1989 to 2009 in an Onco-Hematology Service. Clinical, histological and volumetric data were collected from the medical records. For analysis, chi-square, Kaplan-Meier, log-rank and Cox regression tests were used. RESULTS: The sample consisted of 32 patients, 53.1% were male with a median age at diagnosis of 43 months. There was a significant association between TVAPQ>500mL and the difference between the TVBPQ and TVAPQ (p=0.015) and histologic types of risk (p=0.008). It was also verified an association between the difference between the TVBPQ and TVAPQ and the predominant stromal tumor (p=0.037). When assessing the TVAPQ of all patients, without a cutoff, there was an association of the variable with lifetime (p=0.013), i.e., for each increase of 10mL in TVAPQ there was an average increase of 2% in the risk of death. CONCLUSIONS: Although our results indicate that the TVAPQ could be considered alone as a predictor of poor prognosis regardless of the cutoff suggested in the literature, more studies are needed to replace the histology and staging by tumor size as best prognostic variable.
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spelling pubmed-44369602015-05-20 Tumor size and prognosis in patients with Wilms tumor Provenzi, Valentina Oliveira Rosa, Rafael Fabiano Machado Rosa, Rosana Cardoso Manique Roehe, Adriana Vial dos Santos, Pedro Paulo Albino Faulhaber, Fabrízia Rennó Sodero de Oliveira, Ceres Andréia Vieira Zen, Paulo Ricardo Gazzola Rev Paul Pediatr Original Articles OBJECTIVE: Investigate the relationship of the tumor volume after preoperative chemotherapy (TVAPQ) and before preoperative chemotherapy (TVBPQ) with overall survival at two and at five years, and lifetime. METHODS: Our sample consisted of consecutive patients evaluated in the period from 1989 to 2009 in an Onco-Hematology Service. Clinical, histological and volumetric data were collected from the medical records. For analysis, chi-square, Kaplan-Meier, log-rank and Cox regression tests were used. RESULTS: The sample consisted of 32 patients, 53.1% were male with a median age at diagnosis of 43 months. There was a significant association between TVAPQ>500mL and the difference between the TVBPQ and TVAPQ (p=0.015) and histologic types of risk (p=0.008). It was also verified an association between the difference between the TVBPQ and TVAPQ and the predominant stromal tumor (p=0.037). When assessing the TVAPQ of all patients, without a cutoff, there was an association of the variable with lifetime (p=0.013), i.e., for each increase of 10mL in TVAPQ there was an average increase of 2% in the risk of death. CONCLUSIONS: Although our results indicate that the TVAPQ could be considered alone as a predictor of poor prognosis regardless of the cutoff suggested in the literature, more studies are needed to replace the histology and staging by tumor size as best prognostic variable. Sociedade de Pediatria de São Paulo 2015-03 /pmc/articles/PMC4436960/ /pubmed/25623730 http://dx.doi.org/10.1016/j.rpped.2014.05.003 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Provenzi, Valentina Oliveira
Rosa, Rafael Fabiano Machado
Rosa, Rosana Cardoso Manique
Roehe, Adriana Vial
dos Santos, Pedro Paulo Albino
Faulhaber, Fabrízia Rennó Sodero
de Oliveira, Ceres Andréia Vieira
Zen, Paulo Ricardo Gazzola
Tumor size and prognosis in patients with Wilms tumor
title Tumor size and prognosis in patients with Wilms tumor
title_full Tumor size and prognosis in patients with Wilms tumor
title_fullStr Tumor size and prognosis in patients with Wilms tumor
title_full_unstemmed Tumor size and prognosis in patients with Wilms tumor
title_short Tumor size and prognosis in patients with Wilms tumor
title_sort tumor size and prognosis in patients with wilms tumor
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436960/
https://www.ncbi.nlm.nih.gov/pubmed/25623730
http://dx.doi.org/10.1016/j.rpped.2014.05.003
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