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Tumor size and prognosis in patients with Wilms tumor
OBJECTIVE: Investigate the relationship of the tumor volume after preoperative chemotherapy (TVAPQ) and before preoperative chemotherapy (TVBPQ) with overall survival at two and at five years, and lifetime. METHODS: Our sample consisted of consecutive patients evaluated in the period from 1989 to 20...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade de Pediatria de São Paulo
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436960/ https://www.ncbi.nlm.nih.gov/pubmed/25623730 http://dx.doi.org/10.1016/j.rpped.2014.05.003 |
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author | Provenzi, Valentina Oliveira Rosa, Rafael Fabiano Machado Rosa, Rosana Cardoso Manique Roehe, Adriana Vial dos Santos, Pedro Paulo Albino Faulhaber, Fabrízia Rennó Sodero de Oliveira, Ceres Andréia Vieira Zen, Paulo Ricardo Gazzola |
author_facet | Provenzi, Valentina Oliveira Rosa, Rafael Fabiano Machado Rosa, Rosana Cardoso Manique Roehe, Adriana Vial dos Santos, Pedro Paulo Albino Faulhaber, Fabrízia Rennó Sodero de Oliveira, Ceres Andréia Vieira Zen, Paulo Ricardo Gazzola |
author_sort | Provenzi, Valentina Oliveira |
collection | PubMed |
description | OBJECTIVE: Investigate the relationship of the tumor volume after preoperative chemotherapy (TVAPQ) and before preoperative chemotherapy (TVBPQ) with overall survival at two and at five years, and lifetime. METHODS: Our sample consisted of consecutive patients evaluated in the period from 1989 to 2009 in an Onco-Hematology Service. Clinical, histological and volumetric data were collected from the medical records. For analysis, chi-square, Kaplan-Meier, log-rank and Cox regression tests were used. RESULTS: The sample consisted of 32 patients, 53.1% were male with a median age at diagnosis of 43 months. There was a significant association between TVAPQ>500mL and the difference between the TVBPQ and TVAPQ (p=0.015) and histologic types of risk (p=0.008). It was also verified an association between the difference between the TVBPQ and TVAPQ and the predominant stromal tumor (p=0.037). When assessing the TVAPQ of all patients, without a cutoff, there was an association of the variable with lifetime (p=0.013), i.e., for each increase of 10mL in TVAPQ there was an average increase of 2% in the risk of death. CONCLUSIONS: Although our results indicate that the TVAPQ could be considered alone as a predictor of poor prognosis regardless of the cutoff suggested in the literature, more studies are needed to replace the histology and staging by tumor size as best prognostic variable. |
format | Online Article Text |
id | pubmed-4436960 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Sociedade de Pediatria de São Paulo |
record_format | MEDLINE/PubMed |
spelling | pubmed-44369602015-05-20 Tumor size and prognosis in patients with Wilms tumor Provenzi, Valentina Oliveira Rosa, Rafael Fabiano Machado Rosa, Rosana Cardoso Manique Roehe, Adriana Vial dos Santos, Pedro Paulo Albino Faulhaber, Fabrízia Rennó Sodero de Oliveira, Ceres Andréia Vieira Zen, Paulo Ricardo Gazzola Rev Paul Pediatr Original Articles OBJECTIVE: Investigate the relationship of the tumor volume after preoperative chemotherapy (TVAPQ) and before preoperative chemotherapy (TVBPQ) with overall survival at two and at five years, and lifetime. METHODS: Our sample consisted of consecutive patients evaluated in the period from 1989 to 2009 in an Onco-Hematology Service. Clinical, histological and volumetric data were collected from the medical records. For analysis, chi-square, Kaplan-Meier, log-rank and Cox regression tests were used. RESULTS: The sample consisted of 32 patients, 53.1% were male with a median age at diagnosis of 43 months. There was a significant association between TVAPQ>500mL and the difference between the TVBPQ and TVAPQ (p=0.015) and histologic types of risk (p=0.008). It was also verified an association between the difference between the TVBPQ and TVAPQ and the predominant stromal tumor (p=0.037). When assessing the TVAPQ of all patients, without a cutoff, there was an association of the variable with lifetime (p=0.013), i.e., for each increase of 10mL in TVAPQ there was an average increase of 2% in the risk of death. CONCLUSIONS: Although our results indicate that the TVAPQ could be considered alone as a predictor of poor prognosis regardless of the cutoff suggested in the literature, more studies are needed to replace the histology and staging by tumor size as best prognostic variable. Sociedade de Pediatria de São Paulo 2015-03 /pmc/articles/PMC4436960/ /pubmed/25623730 http://dx.doi.org/10.1016/j.rpped.2014.05.003 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Provenzi, Valentina Oliveira Rosa, Rafael Fabiano Machado Rosa, Rosana Cardoso Manique Roehe, Adriana Vial dos Santos, Pedro Paulo Albino Faulhaber, Fabrízia Rennó Sodero de Oliveira, Ceres Andréia Vieira Zen, Paulo Ricardo Gazzola Tumor size and prognosis in patients with Wilms tumor |
title | Tumor size and prognosis in patients with Wilms tumor |
title_full | Tumor size and prognosis in patients with Wilms tumor |
title_fullStr | Tumor size and prognosis in patients with Wilms tumor |
title_full_unstemmed | Tumor size and prognosis in patients with Wilms tumor |
title_short | Tumor size and prognosis in patients with Wilms tumor |
title_sort | tumor size and prognosis in patients with wilms tumor |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436960/ https://www.ncbi.nlm.nih.gov/pubmed/25623730 http://dx.doi.org/10.1016/j.rpped.2014.05.003 |
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