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Disseminated bronchiectasis in an adult with common variable immunodeficiency
Primary immunodeficiencies (PID) are traditionally considered childhood diseases; however, adults account for 35% of all patients with PID. Antibody deficiencies, especially Common Variable Immunodeficiency (CVID), which have their peak incidence in adulthood, require a high suspicion index. Even th...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Universidad del Valle
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437287/ https://www.ncbi.nlm.nih.gov/pubmed/26019385 |
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author | Zea-Vera, Andrés Felipe Agudelo-Rojas, Olga Lucia |
author_facet | Zea-Vera, Andrés Felipe Agudelo-Rojas, Olga Lucia |
author_sort | Zea-Vera, Andrés Felipe |
collection | PubMed |
description | Primary immunodeficiencies (PID) are traditionally considered childhood diseases; however, adults account for 35% of all patients with PID. Antibody deficiencies, especially Common Variable Immunodeficiency (CVID), which have their peak incidence in adulthood, require a high suspicion index. Even though the estimated frequency of CVID is not high (1:25,000), high rates of under diagnosis and under reporting are very likely. The delay in diagnosis increases the morbidity and mortality; therefore, adult physicians should be able to suspect, identify and initiate management of individuals with PID. Here we report the case of a 37 year-old man presenting to the emergency room with dyspnea, fever and cough; he developed respiratory failure requiring mechanical ventilation. He complained of recurring pneumonia associated with widespread bronchiectasis since he was 18 years old. Serum immunoglobulins quantification showed severe hypogammaglobulinemia (total IgG <140 mg/dL; total IgA, 2.9 mg/dL; and total IgM <5 mg/dL). Treatment with Human Intravenous Immunoglobulin (IVIG) 10% was started, and with antibiotic treatment for severe pneumonia (during 14 days) was also prescribed. His clinical evolution has been favorable after one year follow-up. Common Variable Immunodeficiency (CVID) diagnosis was made. |
format | Online Article Text |
id | pubmed-4437287 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Universidad del Valle |
record_format | MEDLINE/PubMed |
spelling | pubmed-44372872015-05-27 Disseminated bronchiectasis in an adult with common variable immunodeficiency Zea-Vera, Andrés Felipe Agudelo-Rojas, Olga Lucia Colomb Med (Cali) Case Report Primary immunodeficiencies (PID) are traditionally considered childhood diseases; however, adults account for 35% of all patients with PID. Antibody deficiencies, especially Common Variable Immunodeficiency (CVID), which have their peak incidence in adulthood, require a high suspicion index. Even though the estimated frequency of CVID is not high (1:25,000), high rates of under diagnosis and under reporting are very likely. The delay in diagnosis increases the morbidity and mortality; therefore, adult physicians should be able to suspect, identify and initiate management of individuals with PID. Here we report the case of a 37 year-old man presenting to the emergency room with dyspnea, fever and cough; he developed respiratory failure requiring mechanical ventilation. He complained of recurring pneumonia associated with widespread bronchiectasis since he was 18 years old. Serum immunoglobulins quantification showed severe hypogammaglobulinemia (total IgG <140 mg/dL; total IgA, 2.9 mg/dL; and total IgM <5 mg/dL). Treatment with Human Intravenous Immunoglobulin (IVIG) 10% was started, and with antibiotic treatment for severe pneumonia (during 14 days) was also prescribed. His clinical evolution has been favorable after one year follow-up. Common Variable Immunodeficiency (CVID) diagnosis was made. Universidad del Valle 2015-03-30 /pmc/articles/PMC4437287/ /pubmed/26019385 Text en http://creativecommons.org/licenses/by/3.0/ © 2015 Universidad del Valle. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited |
spellingShingle | Case Report Zea-Vera, Andrés Felipe Agudelo-Rojas, Olga Lucia Disseminated bronchiectasis in an adult with common variable immunodeficiency |
title | Disseminated bronchiectasis in an adult with common variable immunodeficiency |
title_full | Disseminated bronchiectasis in an adult with common variable immunodeficiency |
title_fullStr | Disseminated bronchiectasis in an adult with common variable immunodeficiency |
title_full_unstemmed | Disseminated bronchiectasis in an adult with common variable immunodeficiency |
title_short | Disseminated bronchiectasis in an adult with common variable immunodeficiency |
title_sort | disseminated bronchiectasis in an adult with common variable immunodeficiency |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437287/ https://www.ncbi.nlm.nih.gov/pubmed/26019385 |
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