Cargando…

The pluripotency factor NANOG promotes the formation of squamous cell carcinomas

NANOG is a key pluripotency factor in embryonic stem cells that is frequently expressed in squamous cell carcinomas (SCCs). However, a direct link between NANOG and SCCs remains to be established. Here, we show that inducible overexpression of NANOG in mouse skin epithelia favours the malignant conv...

Descripción completa

Detalles Bibliográficos
Autores principales:	Palla, Adelaida R., Piazzolla, Daniela, Alcazar, Noelia, Cañamero, Marta, Graña, Osvaldo, Gómez-López, Gonzalo, Dominguez, Orlando, Dueñas, Marta, Paramio, Jesús M., Serrano, Manuel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437308/ https://www.ncbi.nlm.nih.gov/pubmed/25988972 http://dx.doi.org/10.1038/srep10205

Ejemplares similares

Nanog Is the Gateway to the Pluripotent Ground State
por: Silva, Jose, et al.
Publicado: (2009)

Esrrb Is a Direct Nanog Target Gene that Can Substitute for Nanog Function in Pluripotent Cells
por: Festuccia, Nicola, et al.
Publicado: (2012)

NaNog: A pluripotency homeobox (master) molecule
por: Allouba, Mona H., et al.
Publicado: (2015)

Context-Dependent Functions of NANOG Phosphorylation in Pluripotency and Reprogramming
por: Saunders, Arven, et al.
Publicado: (2017)

The pluripotency factor NANOG controls primitive hematopoiesis and directly regulates Tal1
por: Sainz de Aja, Julio, et al.
Publicado: (2019)

Nanog Overcomes Reprogramming Barriers and Induces Pluripotency in Minimal Conditions
por: Theunissen, Thorold W., et al.
Publicado: (2011)

Nanog, Oct4 and Tet1 interplay in establishing pluripotency
por: Olariu, Victor, et al.
Publicado: (2016)

Prognostic Significance of the Pluripotency Factors NANOG, SOX2, and OCT4 in Head and Neck Squamous Cell Carcinomas
por: Pedregal-Mallo, Daniel, et al.
Publicado: (2020)

Nanog-dependent function of Tet1 and Tet2 in establishment of pluripotency
por: Costa, Yael, et al.
Publicado: (2013)

NANOG initiates epiblast fate through the coordination of pluripotency genes expression
por: Allègre, Nicolas, et al.
Publicado: (2022)

A Novel Tumor suppressor network in squamous malignancies
por: Costa, Clotilde, et al.
Publicado: (2012)

CD44v6, STn & O-GD2: promising tumor associated antigens paving the way for new targeted cancer therapies
por: Lodewijk, Iris, et al.
Publicado: (2023)

Nanog Is an Essential Factor for Induction of Pluripotency in Somatic Cells from Endangered Felids
por: Verma, Rajneesh, et al.
Publicado: (2013)

NANOG Amplifies STAT3 Activation and They Synergistically Induce the Naive Pluripotent Program
por: Stuart, Hannah T., et al.
Publicado: (2014)

USP21 deubiquitylates Nanog to regulate protein stability and stem cell pluripotency
por: Liu, Xingyu, et al.
Publicado: (2016)

Cops2 promotes pluripotency maintenance by Stabilizing Nanog Protein and Repressing Transcription
por: Zhang, Weiyu, et al.
Publicado: (2016)

NANOG expression in parthenogenetic porcine blastocysts is required for intact lineage specification and pluripotency
por: Lee, Mingyun, et al.
Publicado: (2023)

Nanog regulates Pou3f1 expression at the exit from pluripotency during gastrulation
por: Barral, Antonio, et al.
Publicado: (2019)

SRSF3 promotes pluripotency through Nanog mRNA export and coordination of the pluripotency gene expression program
por: Ratnadiwakara, Madara, et al.
Publicado: (2018)

Expression of NANOG and Its Regulation in Oral Squamous Cell Carcinoma
por: Grubelnik, Gašper, et al.
Publicado: (2020)

Hypoblast Formation in Bovine Embryos Does Not Depend on NANOG
por: Springer, Claudia, et al.
Publicado: (2021)

The pluripotency factor Nanog regulates pericentromeric heterochromatin organization in mouse embryonic stem cells
por: Novo, Clara Lopes, et al.
Publicado: (2016)

PHC1 maintains pluripotency by organizing genome-wide chromatin interactions of the Nanog locus
por: Chen, Li, et al.
Publicado: (2021)

Enhanced Chemosensitivity by Targeting Nanog in Head and Neck Squamous Cell Carcinomas
por: Huang, Chuan-En, et al.
Publicado: (2014)

Autochthonous Mouse Melanoma and Mammary Tumors do not Express the Pluripotency Genes Oct4 and Nanog
por: Schreiber, Caroline, et al.
Publicado: (2013)

Dax1 and Nanog act in parallel to stabilize mouse embryonic stem cells and induced pluripotency
por: Zhang, Junlei, et al.
Publicado: (2014)

Peroxisome Proliferator-Activated Receptor α Agonist and Its Target Nanog Cooperate to Induce Pluripotency
por: Lee, Jungwoon, et al.
Publicado: (2018)

NANOG prion-like assembly mediates DNA bridging to facilitate chromatin reorganization and activation of pluripotency
por: Choi, Kyoung-Jae, et al.
Publicado: (2022)

AKT1 induces Nanog promoter in a SUMOylation-dependent manner in different pluripotent contexts
por: Francia, Marcos Gabriel, et al.
Publicado: (2023)

The Embryonic Key Pluripotent Factor NANOG Mediates Glioblastoma Cell Migration via the SDF1/CXCR4 Pathway
por: Sánchez-Sánchez, Ana Virginia, et al.
Publicado: (2021)

Nocodazole Treatment Decreases Expression of Pluripotency Markers Nanog and Oct4 in Human Embryonic Stem Cells
por: Kallas, Ade, et al.
Publicado: (2011)

Nanog Variability and Pluripotency Regulation of Embryonic Stem Cells - Insights from a Mathematical Model Analysis
por: Glauche, Ingmar, et al.
Publicado: (2010)

The pluripotency transcription factor Nanog represses glutathione reductase gene expression in mouse embryonic stem cells
por: Solari, Claudia, et al.
Publicado: (2019)

SOX2, OCT4 and NANOG: The core embryonic stem cell pluripotency regulators in oral carcinogenesis
por: Swain, Niharika, et al.
Publicado: (2020)

Transcriptional properties of human NANOG1 and NANOG2 in acute leukemic cells
por: Eberle, Irina, et al.
Publicado: (2010)

Tackling tumor microenvironment through epigenetic tools to improve cancer immunotherapy
por: Lodewijk, Iris, et al.
Publicado: (2021)

Increased expression of the pluripotency markers sex-determining region Y-box 2 and Nanog homeobox in ovarian endometriosis
por: Song, Yong, et al.
Publicado: (2014)

Analyzing bovine OCT4 and NANOG enhancer activity in pluripotent stem cells using fluorescent protein reporters
por: Huang, Delun, et al.
Publicado: (2018)

On the Origin and Evolutionary History of NANOG
por: Scerbo, Pierluigi, et al.
Publicado: (2014)

Nanog Heterogeneity: Tilting at Windmills?
por: Smith, Austin
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_4jep068bfflrfbns3mbjhjp17d