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Association between Argyrophilic Proteins of Nucleolar Organizer Regions, Clinicomorphological Parameters, and Survival in Non-Small-Cell Lung Cancer
We studied argyrophilic proteins associated with nucleolar organizer regions (AgNOR) in non-small-cell cancer. We determined the area index (AI) and coefficient of variation (CV) of AgNOR. AI is associated with the key clinicomorphological parameters within the TNM system: T and N values, greatest t...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437406/ https://www.ncbi.nlm.nih.gov/pubmed/26316948 http://dx.doi.org/10.1155/2014/891917 |
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author | Kobyakov, Dmitriy Klimachev, Vladimir Avdalyan, Ashot Bobrov, Igor Bychkova, Elena Kruglova, Natalia Lazarev, Aleksandr Lushnikova, Elena Nepomnyashchikh, Lev |
author_facet | Kobyakov, Dmitriy Klimachev, Vladimir Avdalyan, Ashot Bobrov, Igor Bychkova, Elena Kruglova, Natalia Lazarev, Aleksandr Lushnikova, Elena Nepomnyashchikh, Lev |
author_sort | Kobyakov, Dmitriy |
collection | PubMed |
description | We studied argyrophilic proteins associated with nucleolar organizer regions (AgNOR) in non-small-cell cancer. We determined the area index (AI) and coefficient of variation (CV) of AgNOR. AI is associated with the key clinicomorphological parameters within the TNM system: T and N values, greatest tumor dimension up to 3 cm and more, disease stage, histogenesis, and tumor differentiation. CV is associated with T value, greatest tumor dimension up to 3 cm and more, histogenesis, and tumor differentiation. Survival of patients is longer in low AI or CV values versus high AI or CV values, longer in low AI and CV values (−AI/−CV type), shorter in high AI and CV values (+AI/+CV type), and intermediate in opposite AI and CV values (−AI/+CV and +AI/−CV types). Independent predictors in non-small-cell lung cancer include N value, greatest tumor dimension, histogenesis, and CV. Assessment of quantitative values and heterogeneity of AgNOR is important for differential diagnosis and prognosis of non-small-cell lung cancer. |
format | Online Article Text |
id | pubmed-4437406 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-44374062015-08-27 Association between Argyrophilic Proteins of Nucleolar Organizer Regions, Clinicomorphological Parameters, and Survival in Non-Small-Cell Lung Cancer Kobyakov, Dmitriy Klimachev, Vladimir Avdalyan, Ashot Bobrov, Igor Bychkova, Elena Kruglova, Natalia Lazarev, Aleksandr Lushnikova, Elena Nepomnyashchikh, Lev Lung Cancer Int Research Article We studied argyrophilic proteins associated with nucleolar organizer regions (AgNOR) in non-small-cell cancer. We determined the area index (AI) and coefficient of variation (CV) of AgNOR. AI is associated with the key clinicomorphological parameters within the TNM system: T and N values, greatest tumor dimension up to 3 cm and more, disease stage, histogenesis, and tumor differentiation. CV is associated with T value, greatest tumor dimension up to 3 cm and more, histogenesis, and tumor differentiation. Survival of patients is longer in low AI or CV values versus high AI or CV values, longer in low AI and CV values (−AI/−CV type), shorter in high AI and CV values (+AI/+CV type), and intermediate in opposite AI and CV values (−AI/+CV and +AI/−CV types). Independent predictors in non-small-cell lung cancer include N value, greatest tumor dimension, histogenesis, and CV. Assessment of quantitative values and heterogeneity of AgNOR is important for differential diagnosis and prognosis of non-small-cell lung cancer. Hindawi Publishing Corporation 2014 2014-01-02 /pmc/articles/PMC4437406/ /pubmed/26316948 http://dx.doi.org/10.1155/2014/891917 Text en Copyright © 2014 Dmitriy Kobyakov et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Kobyakov, Dmitriy Klimachev, Vladimir Avdalyan, Ashot Bobrov, Igor Bychkova, Elena Kruglova, Natalia Lazarev, Aleksandr Lushnikova, Elena Nepomnyashchikh, Lev Association between Argyrophilic Proteins of Nucleolar Organizer Regions, Clinicomorphological Parameters, and Survival in Non-Small-Cell Lung Cancer |
title | Association between Argyrophilic Proteins of Nucleolar Organizer Regions, Clinicomorphological Parameters, and Survival in Non-Small-Cell Lung Cancer |
title_full | Association between Argyrophilic Proteins of Nucleolar Organizer Regions, Clinicomorphological Parameters, and Survival in Non-Small-Cell Lung Cancer |
title_fullStr | Association between Argyrophilic Proteins of Nucleolar Organizer Regions, Clinicomorphological Parameters, and Survival in Non-Small-Cell Lung Cancer |
title_full_unstemmed | Association between Argyrophilic Proteins of Nucleolar Organizer Regions, Clinicomorphological Parameters, and Survival in Non-Small-Cell Lung Cancer |
title_short | Association between Argyrophilic Proteins of Nucleolar Organizer Regions, Clinicomorphological Parameters, and Survival in Non-Small-Cell Lung Cancer |
title_sort | association between argyrophilic proteins of nucleolar organizer regions, clinicomorphological parameters, and survival in non-small-cell lung cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437406/ https://www.ncbi.nlm.nih.gov/pubmed/26316948 http://dx.doi.org/10.1155/2014/891917 |
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