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Association between Argyrophilic Proteins of Nucleolar Organizer Regions, Clinicomorphological Parameters, and Survival in Non-Small-Cell Lung Cancer

We studied argyrophilic proteins associated with nucleolar organizer regions (AgNOR) in non-small-cell cancer. We determined the area index (AI) and coefficient of variation (CV) of AgNOR. AI is associated with the key clinicomorphological parameters within the TNM system: T and N values, greatest t...

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Autores principales: Kobyakov, Dmitriy, Klimachev, Vladimir, Avdalyan, Ashot, Bobrov, Igor, Bychkova, Elena, Kruglova, Natalia, Lazarev, Aleksandr, Lushnikova, Elena, Nepomnyashchikh, Lev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437406/
https://www.ncbi.nlm.nih.gov/pubmed/26316948
http://dx.doi.org/10.1155/2014/891917
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author Kobyakov, Dmitriy
Klimachev, Vladimir
Avdalyan, Ashot
Bobrov, Igor
Bychkova, Elena
Kruglova, Natalia
Lazarev, Aleksandr
Lushnikova, Elena
Nepomnyashchikh, Lev
author_facet Kobyakov, Dmitriy
Klimachev, Vladimir
Avdalyan, Ashot
Bobrov, Igor
Bychkova, Elena
Kruglova, Natalia
Lazarev, Aleksandr
Lushnikova, Elena
Nepomnyashchikh, Lev
author_sort Kobyakov, Dmitriy
collection PubMed
description We studied argyrophilic proteins associated with nucleolar organizer regions (AgNOR) in non-small-cell cancer. We determined the area index (AI) and coefficient of variation (CV) of AgNOR. AI is associated with the key clinicomorphological parameters within the TNM system: T and N values, greatest tumor dimension up to 3 cm and more, disease stage, histogenesis, and tumor differentiation. CV is associated with T value, greatest tumor dimension up to 3 cm and more, histogenesis, and tumor differentiation. Survival of patients is longer in low AI or CV values versus high AI or CV values, longer in low AI and CV values (−AI/−CV type), shorter in high AI and CV values (+AI/+CV type), and intermediate in opposite AI and CV values (−AI/+CV and +AI/−CV types). Independent predictors in non-small-cell lung cancer include N value, greatest tumor dimension, histogenesis, and CV. Assessment of quantitative values and heterogeneity of AgNOR is important for differential diagnosis and prognosis of non-small-cell lung cancer.
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spelling pubmed-44374062015-08-27 Association between Argyrophilic Proteins of Nucleolar Organizer Regions, Clinicomorphological Parameters, and Survival in Non-Small-Cell Lung Cancer Kobyakov, Dmitriy Klimachev, Vladimir Avdalyan, Ashot Bobrov, Igor Bychkova, Elena Kruglova, Natalia Lazarev, Aleksandr Lushnikova, Elena Nepomnyashchikh, Lev Lung Cancer Int Research Article We studied argyrophilic proteins associated with nucleolar organizer regions (AgNOR) in non-small-cell cancer. We determined the area index (AI) and coefficient of variation (CV) of AgNOR. AI is associated with the key clinicomorphological parameters within the TNM system: T and N values, greatest tumor dimension up to 3 cm and more, disease stage, histogenesis, and tumor differentiation. CV is associated with T value, greatest tumor dimension up to 3 cm and more, histogenesis, and tumor differentiation. Survival of patients is longer in low AI or CV values versus high AI or CV values, longer in low AI and CV values (−AI/−CV type), shorter in high AI and CV values (+AI/+CV type), and intermediate in opposite AI and CV values (−AI/+CV and +AI/−CV types). Independent predictors in non-small-cell lung cancer include N value, greatest tumor dimension, histogenesis, and CV. Assessment of quantitative values and heterogeneity of AgNOR is important for differential diagnosis and prognosis of non-small-cell lung cancer. Hindawi Publishing Corporation 2014 2014-01-02 /pmc/articles/PMC4437406/ /pubmed/26316948 http://dx.doi.org/10.1155/2014/891917 Text en Copyright © 2014 Dmitriy Kobyakov et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kobyakov, Dmitriy
Klimachev, Vladimir
Avdalyan, Ashot
Bobrov, Igor
Bychkova, Elena
Kruglova, Natalia
Lazarev, Aleksandr
Lushnikova, Elena
Nepomnyashchikh, Lev
Association between Argyrophilic Proteins of Nucleolar Organizer Regions, Clinicomorphological Parameters, and Survival in Non-Small-Cell Lung Cancer
title Association between Argyrophilic Proteins of Nucleolar Organizer Regions, Clinicomorphological Parameters, and Survival in Non-Small-Cell Lung Cancer
title_full Association between Argyrophilic Proteins of Nucleolar Organizer Regions, Clinicomorphological Parameters, and Survival in Non-Small-Cell Lung Cancer
title_fullStr Association between Argyrophilic Proteins of Nucleolar Organizer Regions, Clinicomorphological Parameters, and Survival in Non-Small-Cell Lung Cancer
title_full_unstemmed Association between Argyrophilic Proteins of Nucleolar Organizer Regions, Clinicomorphological Parameters, and Survival in Non-Small-Cell Lung Cancer
title_short Association between Argyrophilic Proteins of Nucleolar Organizer Regions, Clinicomorphological Parameters, and Survival in Non-Small-Cell Lung Cancer
title_sort association between argyrophilic proteins of nucleolar organizer regions, clinicomorphological parameters, and survival in non-small-cell lung cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437406/
https://www.ncbi.nlm.nih.gov/pubmed/26316948
http://dx.doi.org/10.1155/2014/891917
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